TNF was formerly called cachectin and later termed TNF- a. A protein related to TNF originally termed "lymphotoxin" was also discovered which known as TNF-β. TNF-a is synthesized as a prohormone and then processed intracellularly through successive steps of proteolytic cleavage by enzyme called TNF-a converting enzyme (TACE) to its mature form. ( Joost and Francis, 2001) TNF was formerly called cachectin and later termed TNF- a. A protein related to TNF originally termed "lymphotoxin" was also discovered which known as TNF-β. TNF-a is synthesized as a prohormone and then processed intracellularly through successive steps of proteolytic cleavage by enzyme called TNF-a converting enzyme (TACE) to its mature form. ( Joost and Francis, 2001)
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( Joost and Francis, 2001) TNF was formerly called cachectin and later termed TNF- a. A protein related to TNF originally termed "lymphotoxin" was also discovered which known as TNF-β. TNF-a is synthesized as a prohormone and then processed intracellularly through successive steps of proteolytic cleavage by enzyme called TNF-a converting enzyme (TACE) to its mature form. ( Joost and Francis, 2001) TNF was formerly called cachectin and later termed TNF- a. A protein related to TNF originally termed "lymphotoxin" was also discovered which known as TNF-β. TNF-a is synthesized as a prohormone and then processed intracellularly through successive steps of proteolytic cleavage by enzyme called TNF-a converting enzyme (TACE) to its mature form. ( Joost and Francis, 2001) TNF was formerly called cachectin and later termed TNF- a. A protein related to TNF originally termed "lymphotoxin" was also discovered which known as TNF-β. TNF-a is synthesized as a prohormone and then processed intracellularly through successive steps of proteolytic cleavage by enzyme called TNF-a converting enzyme (TACE) to its mature form. ( Joost and Francis,
( Joost and Francis, 2001) TNF was formerly called cachectin and later termed TNF- a. A protein related to TNF originally termed "lymphotoxin" was also discovered which known as TNF-β. TNF-a is synthesized as a prohormone and then processed intracellularly through successive steps of proteolytic cleavage by enzyme called TNF-a converting enzyme (TACE) to its mature form. ( Joost and Francis, 2001) TNF was formerly called cachectin and later termed TNF- a. A protein related to TNF originally termed "lymphotoxin" was also discovered which known as TNF-β. TNF-a is synthesized as a prohormone and then processed intracellularly through successive steps of proteolytic cleavage by enzyme called TNF-a converting enzyme (TACE) to its mature form. ( Joost and Francis, 2001) TNF was formerly called cachectin and later termed TNF- a. A protein related to TNF originally termed "lymphotoxin" was also discovered which known as TNF-β. TNF-a is synthesized as a prohormone and then processed intracellularly through successive steps of proteolytic cleavage by enzyme called TNF-a converting enzyme (TACE) to its mature form. ( Joost and Francis,