The Theory Of Reservoir Systems Essay

870 Words Dec 26th, 2015 4 Pages
Reservoir Systems consist of a hollow inner core and a polymer membrane, there to control the rate of drug diffusion. Drug diffusion across the membrane is rate limited and controls general drug release rate (Bajpai et al. 2008). For reservoir systems drug release normally remains steady resulting in a zero order profile (Raval, Parikh and Engineer, 2010). Another technology is called the Multiparticulate drug delivery system which consists of microencapsulated granules/beads containing drug packed inside a capsule or compressed into a tablet (Patwekar, and Baramade, 2012). This system is highly fitting to achieve controlled release oral formulations and is advantageous compared to conventional therapy due to the fact that Multiparticulate systems would not have to be administered at frequent times of the day. There are three ways drug can be released from multiparticulate systems, the first being diffusion out of the carrier upon contact with aqueous fluids. The second mode of release is through erosion of outer coatings which will progressively wear away at the outer layer releasing drug at a controlled rate from the bead. Thirdly osmosis can take place, where osmotic pressure builds up inside particle causing drug to be released (Dey, Majumdar and Rao, 2008). SODAS® is a technology that utilises multiparticulate drug delivery and is made up of beads containing a drug core plus any excipients that will control the release. When ingested, water soluble polymers which make…

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