Neuroblastoma and microRNA- 34a is commonly mentioned together in many articles and studies around the world. With the advance in medicine and new discoveries, there has been found a dependence relation of neuroblastoma with these specific type of microRNA since it has been discovered how it could eliminate cancer eternally. MicroRNA-34a has not only revolutionized scientists but the world in general because of its ability to destroy neuroblastoma but also because is a new natural genetic regulator of a tumor suppressor. Its level of dominance allows it to control different processes like apoptosis, metastasis, and differentiation in the cell cycle. MicroRNAs have taken control over diverse organisms, not only humans but also plants
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The human genome has thousands of different types that are usually found in human’s genes and mammals. One of the most important is microRNA-34a. It acts as a regulator of the suppression of tumors in the human body. When cancer is present, transcription factors are not able to bind with the double helix strand because the exact sequence required is not present due to a mutation in the DNA strand. MicroRNA 34a plays the role of the transcription factor that was supposed to stick. Combined with proteins and receptors, microRNA 34a is capable of preventing the division of cell (Misso, …show more content…
When the DNA is damaged, it automatically activates the p53 gene. p53 or usually known as a tumor protein, attaches to miR-34a promoter in order to normalize the expression of microRNAs. p53 eliminates the opportunity for a tumor to occur in correlation with transcriptional targets and having miR-34a to the side in order to avoid any inappropriate cell propagation. Likewise, any damage in the DNA signaling could affect the evolutionary biogenetics process from the p53 gene activation. MicroRNA-34a together with p53, activate SIRT-1, a protein that catalyzes NAD- dependent deacetylation (Rahman, 2011). When SIRT-1 is activated, facilitates the survival of cells through long stages of stress. MicroRNA-34a attaches to SIRT-1 to increment p53 action and move acetyl to different molecules. As this mechanism occurs, it allows to increase and intensify p53 stabilization which would have allowed the cell to be protected with the positive feedback loop. This provides the cell a better living environment where is not being affected by any damages in the DNA or cellular pressure. Bioinformatics estimates propose that a grand amount mRNAs possess equivalents to miR-34a sequence. New studies have discovered how microRNA-34a is crucial in neuroblastoma tumorigenesis, which permits researchers and doctors to observe the power and importance of miR-34a in the human body
The human genome has thousands of different types that are usually found in human’s genes and mammals. One of the most important is microRNA-34a. It acts as a regulator of the suppression of tumors in the human body. When cancer is present, transcription factors are not able to bind with the double helix strand because the exact sequence required is not present due to a mutation in the DNA strand. MicroRNA 34a plays the role of the transcription factor that was supposed to stick. Combined with proteins and receptors, microRNA 34a is capable of preventing the division of cell (Misso, …show more content…
When the DNA is damaged, it automatically activates the p53 gene. p53 or usually known as a tumor protein, attaches to miR-34a promoter in order to normalize the expression of microRNAs. p53 eliminates the opportunity for a tumor to occur in correlation with transcriptional targets and having miR-34a to the side in order to avoid any inappropriate cell propagation. Likewise, any damage in the DNA signaling could affect the evolutionary biogenetics process from the p53 gene activation. MicroRNA-34a together with p53, activate SIRT-1, a protein that catalyzes NAD- dependent deacetylation (Rahman, 2011). When SIRT-1 is activated, facilitates the survival of cells through long stages of stress. MicroRNA-34a attaches to SIRT-1 to increment p53 action and move acetyl to different molecules. As this mechanism occurs, it allows to increase and intensify p53 stabilization which would have allowed the cell to be protected with the positive feedback loop. This provides the cell a better living environment where is not being affected by any damages in the DNA or cellular pressure. Bioinformatics estimates propose that a grand amount mRNAs possess equivalents to miR-34a sequence. New studies have discovered how microRNA-34a is crucial in neuroblastoma tumorigenesis, which permits researchers and doctors to observe the power and importance of miR-34a in the human body