The Side Effects Of Weight Gain Essay

1067 Words Jun 7th, 2016 5 Pages
Among the side effects, weight gain is one of the most common ones that SUs experience with SGAs. Research clearly pointed out that SUs on clozapine and olanzapine are at increased risk of weight gain compared to other antipsychotic medications. Researchers from the Clinical Antipsychotic Trails of Intervention Effectiveness (CATIE) study clearly reported from their clinical trials that SUs on olanzapine medication demonstrated a substantial increase in their weight gain, cholesterol levels, and HbA1c compared to SUs on other medications (Newcomer, 2007). SGAs induced weight gain is a result of blockade of some receptors such as serotonin and adrenergic receptors in the central nervous system, which in turn enhances appetite, increases insulin resistance and decreases insulin secretion causing changes in glucose metabolism. Therefore, these metabolic derangements can result in a risk of developing metabolic syndrome, type2 diabetes and cardiovascular complications (Newcomer, 2007).
Weight gain became one of the major concerns among the SUs using SGAs. Studies clearly indicated the obesity rates doubled in SUs with schizophrenia (Vandyk & Baker, 2012). Weight gain had a great impact on SU’s self-esteem, due to change in their appearance. For example, a SU in my clinical placement was initiated on olanzapine treatment. Her baseline weight was 58 kgs and within three months, she gained 12 kgs. She expressed her frustration by saying “I hate this medication…this medication…

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