Stem cells are the kind of cells that are able to generate embryos and to regenerate adult tissues. Stem cell therapies have the main objective of replacing damaged tissues and modulating inflammation. Tuch BE 2006). This has created a lot of enthusiasm creating regenerative medicine as a new scientific feld, but as every novel therapy, stem cell tretaments face multiple problems. Safety is one of these dilemmas. Some of the main safety concerns are tumorigenicity, biodistribution, immunogenicity and toxicity. (Sharpe et al. 2012). This essay aims to address these aspects and evaluate the safety of stem cell therapies in a wide way. the possibility of stem cells to become a kind of teratoma, a tumor that resembles the germ layers in an
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2006), mainly home to the tissues where they are needed particularly when tissues are damaged or diseasd due to the action of (chavakis et al , 2008) cytokines and chemokines. unfortunately, A large fraction of systemically infused mesenchymal stem cells usually get trapped within the lungs as emboli owing to their large size and cell-surface adhesion receptors. They can also cut blood flow during the pass through capilars (Toma et al., 2009). These arrests prevent the great majority of infused mesenchymal stem cells from homing to damaged or diseased tissues. According to schrepfer et al, 2007, almost 99 …show more content…
Cells which have not the same human leukocyte antigen (HLA) as the host will be recognised as foreign by the immune system. Then these novel cells to the host body may be destroyed even before the therapy works, causing an inflammatory reaction. Immunogenicity takes into consideration multiple factors such as site of administration, how mature the stem cells are, times the cells are administered and the patient immune system (Sleeboom-Faulkner, M., 2013) For a stem cell therapy that comes from a patient 's own cells the risks of immune rejection is pretty low. The cells however, may be exposed to the culture environment that could theoretically alter or add to the cells the potential of an immune rejection. (Zhao et al., 2011). It is therefore essential that these culture conditions are clearly defined and any change should be recognized prior to the adminitsrtion to the
2006), mainly home to the tissues where they are needed particularly when tissues are damaged or diseasd due to the action of (chavakis et al , 2008) cytokines and chemokines. unfortunately, A large fraction of systemically infused mesenchymal stem cells usually get trapped within the lungs as emboli owing to their large size and cell-surface adhesion receptors. They can also cut blood flow during the pass through capilars (Toma et al., 2009). These arrests prevent the great majority of infused mesenchymal stem cells from homing to damaged or diseased tissues. According to schrepfer et al, 2007, almost 99 …show more content…
Cells which have not the same human leukocyte antigen (HLA) as the host will be recognised as foreign by the immune system. Then these novel cells to the host body may be destroyed even before the therapy works, causing an inflammatory reaction. Immunogenicity takes into consideration multiple factors such as site of administration, how mature the stem cells are, times the cells are administered and the patient immune system (Sleeboom-Faulkner, M., 2013) For a stem cell therapy that comes from a patient 's own cells the risks of immune rejection is pretty low. The cells however, may be exposed to the culture environment that could theoretically alter or add to the cells the potential of an immune rejection. (Zhao et al., 2011). It is therefore essential that these culture conditions are clearly defined and any change should be recognized prior to the adminitsrtion to the