NMDAR role in Alzheimer's disease NMDA receptors have many roles in Alzheimer’s disease, First, it is considered as coincidence detectors its important role in synaptic plasticity in encoding the memories by long-term potentiation (LTP) and long-term depression (LTD)(Butterfield & Pocernich, 2003).There are many factors can affect the synaptic strength or alteration in learning and memory, for example, the number NMDA receptors, Glutamate neurotransmitters in presynaptic and postsynaptic sites, degree of excitability of dendritic and postsynaptic membranes and membrane trafficking(Butterfield & Pocernich, 2003), These factors can cause a cognitive impairment related to the synaptic loss and failure.(Butterfield & Pocernich, 2003) The second
