Role Of Gut Microbiota In Therapeutic Effect Of

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Role of gut microbiota in therapeutic effect of metabolic disorder
Diet has been known to regulate the component of intestinal microbes in animal and human subjects. Many trials tried to find out the interaction between the gut microbiota and its host metabolism. They attempted to modulate the dietary to alter different kinds of classical probiotics such as Lactobacillus and Bifobacterium strains and prebiotic for helping to explore the role of gut microbiota in therapeutic effects of metabolic disorders (18). There are some evidences demonstrated that the gut microbiota can reduce the risk of metabolic disease effectively, but there are still very limited studies in animal and human subjects associated with the gut microbiota in therapeutic
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Thus, some investigators tried to use the low fat (2.5%) dahi that a tradition fermented dairy product in India and contain probiotic to treat the type 2 diabetes that cause by high fructose (19). They allocated animals into a normal group, a control group of consumption high fructose and high fructose-treated group for eight weeks (19). Moreover, through the oral glucose tolerance test, blood and tissue sample for the data collection, the result demonstrated most of values such as blood glucose and free fatty acids, plasma insulin and cholesterol were increased significantly in the high fructose-feeding group after the probiotics intervention (19). However, high fructose-treated group that fed by the dahi supplement contain a lower value of those parameters compared to the control group of consumption high fructose. Thus, this result can be illustrated that dahi supplement that contains probiotic lactic acid bacteria can postpone the commencement of glucose intolerance, hyperglycemia and dyslipidemia to decrease the risk of diabetes and other metabolic disorders …show more content…
Some of human clinical trials did not exert a significant effect on reducing the risk of metabolic disease, but certain studies still reveal the positive effects on reducing the occurrence of metabolic disorder. For example, one of those studies has adopt the randomized controlled trial to investigate the probiotics whether affect the glucose metabolism during and after the gestation in Finland. In this trial, two hundred and fifty six pregnant women were randomly assigned to have modified dietary intervention in a double blind method or as a control group (21). The consequence demonstrated the probiotics group has lower blood glucose concentrations compared with the control group during pregnancy. Also, the better glucose tolerance was verified to decline the risk of hyperglycemia and reduce insulin concentration after 12 months’ postpartum period in the probiotics group (21). This effect proved that using dietary intervention to alter the microbiota could make the blood glucose better control even in the normal blood glucose population and provide power evidence for developing the therapeutic treatment in the management of glucose metabolic disease such as diabetes

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