Role Of Gut Microbiota In Therapeutic Effect Of

Improved Essays
Role of gut microbiota in therapeutic effect of metabolic disorder
Diet has been known to regulate the component of intestinal microbes in animal and human subjects. Many trials tried to find out the interaction between the gut microbiota and its host metabolism. They attempted to modulate the dietary to alter different kinds of classical probiotics such as Lactobacillus and Bifobacterium strains and prebiotic for helping to explore the role of gut microbiota in therapeutic effects of metabolic disorders (18). There are some evidences demonstrated that the gut microbiota can reduce the risk of metabolic disease effectively, but there are still very limited studies in animal and human subjects associated with the gut microbiota in therapeutic
…show more content…
Thus, some investigators tried to use the low fat (2.5%) dahi that a tradition fermented dairy product in India and contain probiotic to treat the type 2 diabetes that cause by high fructose (19). They allocated animals into a normal group, a control group of consumption high fructose and high fructose-treated group for eight weeks (19). Moreover, through the oral glucose tolerance test, blood and tissue sample for the data collection, the result demonstrated most of values such as blood glucose and free fatty acids, plasma insulin and cholesterol were increased significantly in the high fructose-feeding group after the probiotics intervention (19). However, high fructose-treated group that fed by the dahi supplement contain a lower value of those parameters compared to the control group of consumption high fructose. Thus, this result can be illustrated that dahi supplement that contains probiotic lactic acid bacteria can postpone the commencement of glucose intolerance, hyperglycemia and dyslipidemia to decrease the risk of diabetes and other metabolic disorders …show more content…
Some of human clinical trials did not exert a significant effect on reducing the risk of metabolic disease, but certain studies still reveal the positive effects on reducing the occurrence of metabolic disorder. For example, one of those studies has adopt the randomized controlled trial to investigate the probiotics whether affect the glucose metabolism during and after the gestation in Finland. In this trial, two hundred and fifty six pregnant women were randomly assigned to have modified dietary intervention in a double blind method or as a control group (21). The consequence demonstrated the probiotics group has lower blood glucose concentrations compared with the control group during pregnancy. Also, the better glucose tolerance was verified to decline the risk of hyperglycemia and reduce insulin concentration after 12 months’ postpartum period in the probiotics group (21). This effect proved that using dietary intervention to alter the microbiota could make the blood glucose better control even in the normal blood glucose population and provide power evidence for developing the therapeutic treatment in the management of glucose metabolic disease such as diabetes

Related Documents

  • Brilliant Essays

    90 % Prokaryotic Analysis

    • 1414 Words
    • 6 Pages

    The study consisted of 36 male adults, with 18 of them having the diabetes. The results showed that the men with type 2 diabetes are associated with compositional changes in intestinal microbiota. When combining microbiota with metabolic diseases (obesity), the glucose level tolerance should be considered. This will broaden more ways to maintain metabolic diseases by modifying the gut microbiota (Larsen,…

    • 1414 Words
    • 6 Pages
    Brilliant Essays
  • Improved Essays

    My father was diagnosed with Type 2 Diabetes and the way it affected him sparked my interest in medicine. At GCSE level, I learnt that diabetes results when the pancreas does not produce enough insulin to maintain a normal blood glucose level. Further interest led me to learn that the most common drug used is metformin, reducing the amount of glucose released. Currently the only way to delay/prevent diabetes in people who may have genetic predispositions to it is by maintaining a healthy weight. Recently, a study in Diabetologia showed that obese people with prediabetes could improve their metabolic health, by avoiding AGE products.…

    • 649 Words
    • 3 Pages
    Improved Essays
  • Improved Essays

    The Second Brain

    • 1013 Words
    • 5 Pages

    Greenblatt “So what cautions do you think that we need to take in this field in order not to overstate the potential of treatment via the gut brain connection?” Dr. Greenblatt response was straight and simple. He expresses how individuals need to take care of our gut and the importance in eating healthy ferment foods that provide healthy bacteria to the human body. It is uncertain as to specifically what probiotics can treat, but we do know that micro biome is healthy. As research has increased, we need to consider taking caution in nutritional supplement companies claiming that they have this probiotic that will treat depression, another probiotic that will treat this, and the end result will be nutritional supplement companies clamming that they have a probiotic to treat a certain disorder or…

    • 1013 Words
    • 5 Pages
    Improved Essays
  • Improved Essays

    “It Takes Guts” is a documentary that talks about the obesity epidemic, and how microbes play a crucial role in affecting the overall size of an individual. “Microbes are defined as single-cell organisms so tiny that millions can fit into the eye of a needle. They are the oldest form of life on earth”. Microbes are mostly found in the guts. In fact, according to the documentary, geneticist Tim Spector states that we are creatures that evolved from microbes and we can not possibly live without them.…

    • 311 Words
    • 2 Pages
    Improved Essays
  • Improved Essays

    Gut Microbiota

    • 621 Words
    • 3 Pages

    Despite the unique bacterial combination of each individual, there seems to be, a specific balance to reach in order for it to be beneficial to our health. It is also suggested, that a decrease in the desirable gastrointestinal bacteria will lead to deterioration in the gastrointestinal neuroendocrine, or immune relationships and lead to…

    • 621 Words
    • 3 Pages
    Improved Essays
  • Great Essays

    Paleo Diet

    • 999 Words
    • 4 Pages

    Paleo diet has become a popular diet, with the goal of imitating the diet of humans from over 10,000 years ago. A brief history on both diets is presented and it is followed by a review of articles The American diet when compared to the diet of humans from over 10,000 years ago, has changed drastically. Food has become more processed as chemicals are added to increase the shelf life of products and artificial ingredients are added to improve the product aesthetically. This has raised the question whether these changes in eating habits and lifestyle are leading to the prevalence of diseases today.…

    • 999 Words
    • 4 Pages
    Great Essays
  • Improved Essays

    The results of this study are similar to the studies discussed above in that Lactobacillus counts did not alter significantly, but Bifidobacterium counts did increase significantly. They indicate that an interesting addition to our study would have been to add two synbiotic feeding groups, Bifidobacterium/FOS and Lactobacillus/FOS. Results from previous studies have shown that an easily accessed, preferred substrate increases the viability of the probiotic.51 In order for all the rats to begin the experiment with a “sterile” gut, they could have been given a round of antibiotics beforehand. Also, although LAC is not significantly higher in this study, it is trending higher. Therefore, it is possible that with a higher n, the result may have become significant.…

    • 386 Words
    • 2 Pages
    Improved Essays
  • Improved Essays

    Bacteria living in the gut can help…

    • 255 Words
    • 2 Pages
    Improved Essays
  • Improved Essays

    Gut Homeostasis

    • 1299 Words
    • 6 Pages

    Probiotics are commonly used to aid in the treatment of gastrointestinal disorders (Cryan and O’Mahony, 2011). However, recently, probiotics are being used as a clinical treatment for reducing anxiety and stress disorders and improving mood (Cryan and O’Mahony, 2011). In clinical trials involving rats and humans, using probiotics containing Lactobacillus helveticus and Bifidobacterium longum showed reduced signs of anxiety and a decrease in serum cortisol levels (Cryan and O’Mahony, 2011). Recently examined clinical trials showed that chronic treatment with Lactobacillus rhamnosus, over a month in duration, resulted in subjects having decreased levels of corticosterone and depressive behaviors, and less anxious phenotypes (Bravo et al., 2011).…

    • 1299 Words
    • 6 Pages
    Improved Essays
  • Great Essays

    Grantham Study Essay

    • 2363 Words
    • 10 Pages

    This indicates that, were the participants in the second tertile to consume the amount of dairy the third tertile is consuming, the incidences of diabetes development could be avoided, which is a very significant statistic. However, according to the results in the study itself, 50% of diabetes would be eliminated by the increase in dairy between the first tertile and third tertile. Both of these rates show that even moderate increases in consumption could have a significant increase on prevention. Question 8: The possible confounders adjusted in this study were age, sex, total energy intake, family history of diabetes, education, physical activity, smoking status, serum cholesterol both fasting serum TAG and HDL-C, systolic blood pressure, waist circumference and hip…

    • 2363 Words
    • 10 Pages
    Great Essays
  • Improved Essays

    It is estimated that nearly 35% of the US population has metabolic syndrome1. Metabolic syndrome encompasses a cluster of disorders that increase risk of cardiovascular disease and type 2 diabetes.2 The GI tract is home to trillions of microorganisms that confer benefits to the host. Recent evidence has implicated alternations in gut microbiota composition and metabolic activity in the pathophysiology of metabolic syndrome3,4. Maintenance of gut barrier function, regulation of immune response and lipogenesis are possible mechanisms through which the gut microbiome influences metabolic syndrome3-5. Diet can be used to modulate gut microbiota composition and function.…

    • 298 Words
    • 2 Pages
    Improved Essays
  • Decent Essays

    Diabetic Kidney Disease

    • 549 Words
    • 3 Pages

    It is known that the more affluent a society, the incidence of diabetes is higher as compared to underdeveloped nations. So, it is the modern lifestyle and dietary that influences the Diabetes condition, causing people to suffer from this sickness. For adult onset type 2 diabetic; study has shown that people who are over-weights and obesity, having higher than normal level of blood glucose; are facing a stronger risk. They are at a greater risk of health complications that involve damage to small blood vessels and nerves that can affect the kidneys, make damages to the kidneys known as (diabetic nephropathy), and leading to kidney failure that needs for dialysis. What is a kidney disease?…

    • 549 Words
    • 3 Pages
    Decent Essays
  • Decent Essays

    Synthesis Lab Hypothesis

    • 265 Words
    • 2 Pages

    The experiment consisted in measuring BIA and gut microbiota before, during and after the intervention. Gut microbiota was analysed through quantitative-real time PCR using the 16S rDNA to identify the bacteria genus present in the gut. The variables are weight loss and gut microbiota, the independent one is weight…

    • 265 Words
    • 2 Pages
    Decent Essays
  • Improved Essays

    Diabetic Reflective Essay

    • 771 Words
    • 4 Pages

    The goal of nutritional management for diabetes mellitus type 2 is to maintain a normal blood glucose levels, blood pressure, and weight to avoid the complications of kidney and cardiovascular disease. In addition, having a severe carbohydrate and calorie can effect on type 2 diabetes management (Kramer and Chang, 2013). The new nutritional guidelines from the American Diabetes Association that no longer use of specific carbohydrate, instead of it, they recommend the patients to have “dietary pattern that includes carbohydrate from fruits, vegetables, whole grains, legumes,and low-fat milk” (Kramer and Chang, 2013). Additionally, the patient should decrease the intake of sodium, saturated fat and trans fat and on other hand increasing fish consumption (Kramer and Chang, 2013). According to the United States news, the dietary approach to stop hypertension (DASH) diet considered the best diet plan for six years in a row.…

    • 771 Words
    • 4 Pages
    Improved Essays
  • Improved Essays

    The aim of this project is to study the human microbiota and the entire analysis of their role in human health and diseases. In the past, the study of microorganisms was generally carried out in laboratories .But, most of the microbial have never been isolated in the laboratory and therefore their growth has been dependent entirely on some specific conditions that were duplicated in the laboratory. Thus, this project is useful tool for researchers and the entire medical field in the study of microorganisms and come up with human…

    • 766 Words
    • 4 Pages
    Improved Essays