Discussion
Catabolic pathways break down substrates for use by the cell - pick one of the catabolic pathways and carry out some background research; what are the inputs and outputs of the pathway? Are the inputs coming from other pathways, or are they scavenged by the cell? Are the intermediates used in any other processes? How ubiquitous is this pathway?
After my reading this week, I had much better understanding on what really takes place during metabolism (catabolic reaction). Purine catabolism pathway is one of the cellular processes that fascinated me the most. I choose to research on this specific process and was able establish a pretty good grasp of what happens in the process of it break down. Purine bases are the adenine and guanine. …show more content…
Under dephosphorylation, AMP, IMP, XMP and GMP molecules are dephosphorylated into their corresponding nucleotides which include Adenosine, Enosine, Xanthosine, Guanosine and the process is catalysed by the enzyme Nucleotidase. In step two, deamination, AMP (Nucleotide) and Adenosine (Nucleoside) is deaminated into IMP and Inosine respectively. This reaction is catalyzed by AMP deaminase and Adenosine deaminase. Guanine (nitrogenous base only) is deaminated into Xanthosine in the presence of the “Guanisine deaminase”. Step 3 handle the glycosidic bond cleavage where the nucleoside Inosine, Xanthosine, Guanosine is converted into Hypoxanthine, Xanthine and Guanine. This reaction is catalyzed by “Purine nucleotide phosphorylase” and In this step the Glycosidic linkage which is present in both N9 of Nitrogenous base and C1 of Sugar molecule will be breath. Subsequently, the hypoxanthine is converted into Xanthine and even further into Uric acid. This reaction is catalyzed by Xanthine Oxidase. The purine catabolic process is found in almost all forms higher animal kingdom. The figure below is diagrammatic flowchart showing how the entire process takes
Catabolic pathways break down substrates for use by the cell - pick one of the catabolic pathways and carry out some background research; what are the inputs and outputs of the pathway? Are the inputs coming from other pathways, or are they scavenged by the cell? Are the intermediates used in any other processes? How ubiquitous is this pathway?
After my reading this week, I had much better understanding on what really takes place during metabolism (catabolic reaction). Purine catabolism pathway is one of the cellular processes that fascinated me the most. I choose to research on this specific process and was able establish a pretty good grasp of what happens in the process of it break down. Purine bases are the adenine and guanine. …show more content…
Under dephosphorylation, AMP, IMP, XMP and GMP molecules are dephosphorylated into their corresponding nucleotides which include Adenosine, Enosine, Xanthosine, Guanosine and the process is catalysed by the enzyme Nucleotidase. In step two, deamination, AMP (Nucleotide) and Adenosine (Nucleoside) is deaminated into IMP and Inosine respectively. This reaction is catalyzed by AMP deaminase and Adenosine deaminase. Guanine (nitrogenous base only) is deaminated into Xanthosine in the presence of the “Guanisine deaminase”. Step 3 handle the glycosidic bond cleavage where the nucleoside Inosine, Xanthosine, Guanosine is converted into Hypoxanthine, Xanthine and Guanine. This reaction is catalyzed by “Purine nucleotide phosphorylase” and In this step the Glycosidic linkage which is present in both N9 of Nitrogenous base and C1 of Sugar molecule will be breath. Subsequently, the hypoxanthine is converted into Xanthine and even further into Uric acid. This reaction is catalyzed by Xanthine Oxidase. The purine catabolic process is found in almost all forms higher animal kingdom. The figure below is diagrammatic flowchart showing how the entire process takes