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The Pros And Cons Of Angiogenesis

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Angiogenesis is complex, dynamic process involving the migration, growth, and differentiation of endothelial cells, and orchestrated by a balance of pro and anti-angiogenic signaling pathways. It is an early and crucial step alleviating the tumour progression and metastasis. Important stimolator of angiogenesis are Vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF2), angiopoietins (ANGPT1 and ANGPT2), Notch ligands [jagged 1 (JAG1) and Delta like ligand 4 (DLL4) and transforming growth factor-β (TGF-β). miRs are important for vascular development, physiology, and disease however, only a few specific miR-NAs targeting angiogenesis have been identified, till date. Downregulation of the miRNA-processing enzymes Dicer and

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