Essay on The Pathophysiology Of A Stroke

1404 Words Dec 5th, 2016 6 Pages
1. Discuss the pathophysiology related to CVA due to thrombus vs. embolus. Describe the stages in the development of an atheroma.
There are a few different pathophysiologies that can lead to a stroke. The most common cause of a stroke is from atheroma, or plaque buildup on the artery wall leading to narrowing and then finally an infarction of the brain, or a stroke (VanMeter & Hubert, 2014, p. 347). The progression of an atherosclerosis, starts with damage to the endothelium of the artery (VanMeter & Hubert, 2014, p. 235). This leads to inflammation and an accumulation of lipids, and white blood cells in the (middle) muscle layer of the vessel (VanMeter & Hubert, 2014, p. 235). This leads to further inflammation and plaque buildup (VanMeter & Hubert, 2014, p. 235). There continues to be buildup of lipids and fibrous tissue at the injury site, and platelets adhere to the site, causing more inflammation and enlarging the thrombus (VanMeter & Hubert, 2014, p.235-6). As the thrombus grows, the blood flow becomes more turbulent leading to more thrombus formation (VanMeter & Hubert, 2014, p. 236). If the atheroma is in the in a cerebral artery like the carotid, when the lumen is totally occluded from the thrombus there is no blood flow to part of the brain, meaning that the patient is having an ischemic stroke (VanMeter & Hubert, 2014, p. 347). If there is a thrombus in the arteries that supply blood to the brain, then there are often warning signs of a problem, call TIAs or…

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