The Importance Of The Human Immune System
The innate immune system comprises of four distinct barriers; i) physiological barriers ii) the epithelial barriers including skin and mucosal surfaces iii) molecular barriers including complement system, mannose binding lectin, C-reactive proteins, antimicrobial proteins and peptides etc. and vi) cellular barriers …show more content…
It has been shown that during an episode of pneumonia, infants have increased levels of antimicrobial peptides in their lungs(29).
Invasive fungal infections(31)
Preterm infants are deficient in many circulating AMPs(32). At mucosal surfaces, such as within the gut, preterm infants have lower expression levels of certain AMPs(33) which has been proposed to contribute to their susceptibility to NEC(34).
FOCUS ON LL-37 AND BPI AS POTENTIAL THERAPEUTICS
Topical imiquimod for anogenital warts (35)
A recent review has covered the therapeutic potential of AMPs for therapeutic intervention