Cell division is the process by which a single “parent” cell divides and produces identical "daughter" cells. This process occurs in living organisms in order to create new cells. Mitosis is the division of a cell’s nucleus. It is responsible for cell regeneration, growth, and asexual reproduction. Not only does mitosis plays an important role in cell division, but it also plays an important role in the spreading of cancer cells.
Mitosis has 4 stages, prophase, metaphase, anaphase and telophase. During prophase, the nucleoli disappears and chromatin fibers coil up becoming discrete chromosomes. Each chromosome consists of two identical sister chromatids, joined at the centromere. Microtubules grow out from the centrosomes, initiation the …show more content…
Mitosis is a new main focus of scientific advances in the killing of cancer cells. Even so, it has allowed the identification of mitotic targets and strategies for clinical use. According to Killing cells by targeting mitosis, a recent study suggests that “...targeting mitotic exit by inhibiting the anaphase-promoting complex generates metaphase cells that invariably die in mitosis” (Manchado, Guillamot, Malumbres, 2012). The efficiency of targeting the cell-cycle is limited for now and this is why approaches have been limited so far. The biggest challenge with the antimitotic drugs that are being produced to target the cancerous cells are that they are very sensitive and the human body is very complex. According to Mitosis-targeted anti-cancer therapies: where they stand “The majority of newer mitosis-targeting drugs currently under development could not translate their preclinical efficacy to clinical response in human trials (Chan, Koh, Li, 2012).” In order to move further in these projects, a greater understanding of the molecular pathways modulating mitotic cell death must be required. The conflict that takes place in this study is being able to discriminate the tumor and the multiplying normal cells “the development of mitosis-selective inhibitors, the unpredictable complexities of the human body 's response to these drugs still herald the biggest challenge towards clinical success (Chan, Koh, Li, 2012).” The study conductors have been targeting cells at their vulnerable state of mitosis to see the possibilities of putting an end to cancer cells before the cells become more
Mitosis has 4 stages, prophase, metaphase, anaphase and telophase. During prophase, the nucleoli disappears and chromatin fibers coil up becoming discrete chromosomes. Each chromosome consists of two identical sister chromatids, joined at the centromere. Microtubules grow out from the centrosomes, initiation the …show more content…
Mitosis is a new main focus of scientific advances in the killing of cancer cells. Even so, it has allowed the identification of mitotic targets and strategies for clinical use. According to Killing cells by targeting mitosis, a recent study suggests that “...targeting mitotic exit by inhibiting the anaphase-promoting complex generates metaphase cells that invariably die in mitosis” (Manchado, Guillamot, Malumbres, 2012). The efficiency of targeting the cell-cycle is limited for now and this is why approaches have been limited so far. The biggest challenge with the antimitotic drugs that are being produced to target the cancerous cells are that they are very sensitive and the human body is very complex. According to Mitosis-targeted anti-cancer therapies: where they stand “The majority of newer mitosis-targeting drugs currently under development could not translate their preclinical efficacy to clinical response in human trials (Chan, Koh, Li, 2012).” In order to move further in these projects, a greater understanding of the molecular pathways modulating mitotic cell death must be required. The conflict that takes place in this study is being able to discriminate the tumor and the multiplying normal cells “the development of mitosis-selective inhibitors, the unpredictable complexities of the human body 's response to these drugs still herald the biggest challenge towards clinical success (Chan, Koh, Li, 2012).” The study conductors have been targeting cells at their vulnerable state of mitosis to see the possibilities of putting an end to cancer cells before the cells become more