Heterogeneity Of Cancer

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Invasive cancer is the cancer that spreads beyond the layer of tissue which developed and is growing into surrounding, healthy tissues. A lot of physicians try to detect and prevent the invasive cancers. Ductal carcinoma in situ is a non-invasive breast cancer. It does not spread beyond the milk duct into surrounding breast tissue. However, it can increase the risk of having invasive breast cancer later. Heterogeneity is a word that means diversity. It signifies the quality of state of being heterogeneous. Heterogeneity of cancer becomes important to treat and understand the cancer. Population bottleneck is a rapid reduction in the size of a population due to environmental events. Genetically diverse tumor has greater possibility to survive. …show more content…
A lot of physicians have been questioning how to treat and distinguish the precancerous cancers, non-invasive cancers, that could remain harmless or become invasive. Scientists try to understand by tracing cancer’s inherent heterogeneity. Cancer cells have unstable genomes that their chromosomes can gain or lose pieces with rapid speed, creating genetically diverse population. Now, researchers track the individual cancer cells more precisely which helps to know more about origins of cancer and how to improve treatments. Scientists find out that since pre-invasive cancer cells are highly unstable and potential to spread, those cells should be treated. With a genetically diverse tumor, there is a good chance that a few cells will survive when whole other cells die. With current technology, scientists are able to analyze the individual cancer cells in perspective of evolutionary biology which could help them pinpoint its cancer’s adaption and unlimited growth. When cancer cells reproduce, there is always a risk of error which DNA is mistakenly copied, chromosomes misalign, and break up into wrong cell. The new evolutionary approach, a phylogenetic tree, allows scientists to calculate which genes are more likely to be copied or die and become grow or survive. The tree approach is better to predict which primary tumors later metastasize. Other scientists are now starting to examine …show more content…
With the developed technology and the phylogenetic tree method, scientists are now able to investigate genes and cells individually to distinguish whether precancerous cells would become invasive cancer cells or not. Like general evolutionary biology notion, they find out cancer cells are also diverse genetically and more likely to survive in the changing environment. Some certain cancer cells may be empowered and adapt. So, they conclude even genetically diverse precancerous cells should be treated because they might hide their ability to spread. It was interesting that there is precancerous cells which does not spread around the body tissues but may become invasive. Also, it was surprising that the technology is so developed that scientists now can analyze every single cancer cell not average of them. Furthermore, just like other organisms, the more genetically diverse cancer cells, the higher chance to survive in changing environments. I would like to introduce this article to classmates because this article might be helpful to give some idea that how our current cancer research is improved and know about precancerous and cancer cell research. It will be long way to go; however, we are able to find treatment and cure the cancer completely

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