Essay on The Genetic Disease Sickle Cell Anemia

1554 Words Nov 18th, 2016 7 Pages
Title-
The Genetic Disease Sickle Cell Anemia
Introduction-
Throughout evolutionary history, advances in molecular biology allow molecular biologist to discover new genetic diseases. Sickle cell anemia is an inherited blood disorder in which there is a single amino acid substitution, which alters the structure and function of the hemoglobin. Although one might think that this disease only affects the circulatory system it actually affects many of the body’s systems, disrupting its functional processes. People who have sickle cell anemia have different severity of symptoms. Some may have reoccurring sickness and trouble breathing while others would have a greater difficulty to breathe leading them to no longer survive. Not only is the anatomy of the blood cell causing a lack of oxygen storage but the blood cell is also oddly shaped which caused it to clog blood vesicles more frequently and in more extreme cases shear the vesicle. Although this disease seems to be non-beneficial to the population, in some areas it is still selected for. 5, 7
Nature of the Genetic Mutation Behind the Disease- Sickle cell anemia is an inherited blood disorder in which there is a single amino acid substitution, which alters the structure and function of the hemoglobin. More specifically, it is a result of a Glu→Val substitution in the β-globin within the protein hemoglobin. This substitution is identified as a mis-sense mutation since one amino acid is replaced resulting in an overall change…

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