The Formula Of Metronidazole
Systematic (IUPAC) name: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol
: 80% (oral), 60-80% (rectal), 20-25% (vaginal)122,123
: 20% 122,123
: Hepatic 122,123
: 8 hours 122,123
: Urine (77%), faeces (14%) 122,123
: 171.15 g/mol
: 159–163 °C (318–325 °F)
Metronidazole is a nitroimidazoleantibiotic medication used particularly for anaerobic bacteria and protozoa. Metronidazole is an antibacterial against anaerobic organisms, amoebicide and antiprotozoal.124 It is the drug of choice for first episodes of mild-to-moderate Clostridium difficile infection.125
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic …show more content…
Lecithin is a complex mixture of materials; see Section 4. The structure above shows phosphatidylcholine, the principal component of egg lecithin, in its a-form. In the b-form, the phosphorus-containing group and the R2 group exchange positions.
6 Functional Category
Emollient; emulsifying agent; solubilizing agent.
7 Applications in Pharmaceutical Formulation or Technology
Lecithins are used in a wide variety of pharmaceutical applications; see Table No. 3.5. They are also used in cosmetics and food products. Lecithins are mainly used in pharmaceutical products as dispersing, emulsifying, and stabilizing agents and are included in intramuscular and intravenous injections, parenteral nutrition formulations, and topical products such as creams and ointments. Lecithins are also used in suppository bases, to reduce the brittleness of suppositories, and have been investigated for their absorption-enhancing properties in an intranasal insulin formulation.
Table No. 3.5 : Uses of lecithin.
Use Concentration (%)
Aerosol inhalation 0.1
IM injection 0.3–2.3
Oral suspensions 0.25–10.0