The Distribution of Alu Genotypes Essay

2161 Words Jan 29th, 2013 9 Pages
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Essay Sample: Page 2
ACE



n = 31

Total alleles = 62



2 (+ +) 4 + alleles

14 (+ -) 14 + alleles 14 – alleles

15 (- -) 30 – alleles



Frequency of + allele = Total number of + alleles

Total alleles



Frequency of + allele = 18

62



Frequency of + allele = 0.29



Frequency of - allele = Total number of + alleles

Total alleles



Frequency of - allele = 44

62



Frequency of - allele = 0.71



The Hardy Weinberg Equilibrium equation is as follows, with the fraction of + alleles denoted by p and the fraction of – alleles denoted by q.

p2 + 2pq + q2 = 1



0.292 + 2(0.29)(0.71) + 0.712 = 1

0.0841 + 0.4118 + 0.5041 = 1



Expected number of individuals with (+ +) genotype = p2N

= 0.0841 X 31

= 2.6071



Expected number of individuals with (+ -) genotype = 2pq

= 0.4118 X 31

= 12.7658



Expected number of individuals with (- -) genotype =
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