In C.elegans, great diversity of species-specific KCs fine-tune neuronal properties. TWK mRNA editing works as an adaptive mechanism to improve neuronal computing, regulating i.a. movement, egg-lying and defecation. Presence of additional membrane conductances, such as SLO-2, which function under abnormal physiological conditions, provide a selective advantage for C.elegans to cope with various environmental challenges (ex.hypoxia). Octopuses, on the other hand, benefit from Kv1 mRNA editing which serves as a long-term adaptation (or rapid acclimation) for species inhabiting different temperature ranges. In mammalian brains, different dendritic KCs play different roles in neuronal signalling -Kir channels regulate membrane resting potential and play an important role in synaptic integration, while A-type KCs regulate AP back-propagation and underlie mechanisms of LTP and synaptic
In C.elegans, great diversity of species-specific KCs fine-tune neuronal properties. TWK mRNA editing works as an adaptive mechanism to improve neuronal computing, regulating i.a. movement, egg-lying and defecation. Presence of additional membrane conductances, such as SLO-2, which function under abnormal physiological conditions, provide a selective advantage for C.elegans to cope with various environmental challenges (ex.hypoxia). Octopuses, on the other hand, benefit from Kv1 mRNA editing which serves as a long-term adaptation (or rapid acclimation) for species inhabiting different temperature ranges. In mammalian brains, different dendritic KCs play different roles in neuronal signalling -Kir channels regulate membrane resting potential and play an important role in synaptic integration, while A-type KCs regulate AP back-propagation and underlie mechanisms of LTP and synaptic