MUC1: A Preventive Agent Against Helicobacter

It has been demonstrated that MUC1 (membrane bound mucin) often located on the outer portions of cells, serves as a preventive agent against Helicobacter pylori. MUC1 reduces gastric inflammation in H. pylori Infected tissue by forming a complex with IkB kinase gamma (IKKγ) in this way hindering the contact between IKKγ and IKKβ causing the prevention of nuclear factor kappa B (NF-kB) transportation to the nucleus, in this manner preventing the transcription of genes that can cause inflammation [4]. The adhesive properties of Helicobacter pylori are crucial during the initial phase of the stomach colonization as wells for survival since attachment provide the means by which H. pylori obtains nutrients [116]. H. pylori possess two major adhesion molecules of BabA and SabA. The blood group antigen binding adhesion (Bab A) allows Helicobacter pylori connect to the Lewis b blood group antigen and H antigen type 1 …show more content…
pylori [123]. During an ongoing infection of Helicobacter pylori, macrophages display an increase level of SMO, which results in mitochondrial mediated apoptosis and the release of hydrogen peroxide into the extracellular space causing the damage of adjacent epithelial cells in the stomach [124] Recent publications argue that Helicobacter pylori causes an increase in the amount inducible NO synthase (iNOS) and NO [125]. At the same time arginase II is induced which results in the generation of ornithine and ornithine decarboxylase triggering the generation of polyamines. Spermine, a polyamine impede the proinflammation response; by inhibiting induce NO synthase and NO production [126]. This allows the Helicobacter pylori to sustain and prolong its survival in the stomach [125, 126]