Introduction The percentage of men over 40 using testosterone replacement therapy (TRT) tripled from 2001 to 2011¹. Newer, gel based forms of treatment have aided the ease of application and encouraged prescription rates. Along with this trend comes an increase in the data surrounding TRT. This influx adds to the large scale, randomized studies conducted on the use of TRT in hypogonadal men. TRT is widely accepted to provide relief from retarded spermatogenesis, low sex function, depression, and bone fiber deterioration in aging men. While testosterone is associated with facial hair, libido, and increased muscle growth it is also important to consider testosterones hematopoietic effects. These treatments are used by females, however, pharmaceutical
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Transmucosal administration prevents skin irritation, adhesion problems, and unwanted transference of androgen. Intranasal methods allow rapid delivery of TRT, culminating in only seconds of application per day. After a screening period for nasal inflammation, drug abuse, and prostate enlargement, hypogonadal males averaging 54.4 years of age engaged in TRT over the course of 90 days5. The experimental tests of transmucosal TRT gel show an increase to normalized levels of testosterone in 73 percent of the testing population. Out of 306 subjects, one man had a severe treatment-emergent adverse event of myalgia which did not warrant the discontinuation of the test drug. After the patients concluded the study, “nearly 70% subjects previously treated with another TRT said that they would be willing to switch to Natesto, suggesting that the multiple daily dosing was not a major inconvenience.” Thanks to gel based testosterones, patients can apply a TRT most adequate for their needs and continue to prevent low …show more content…
Researchers conducted a study of 149,354 men diagnosed with PC–including 1,181 men who received TRT4. Overall, TRT was not associated with PC deaths. Furthermore, researchers reported on 103 men who were treated with TRT after a prostatectomy. The trial showed no evidence of cancer resurgence after 3 years of investigation. These studies led researchers to hypothesize the therapeutic role of testosterone in prostate cancer.
Scientists are currently requesting additional study on the apoptosis of androgen-independent PC cells. The characteristics of the mutated prostatic cells would cease replication when exposed to testosterone-albumin complex, while allowing the prostatic membrane to remain intact. The increase in division of PC cells due to testosterone addition in mice has been observed. The theory of anti androgen application in PC has been theorized but not yet tested.
Transmucosal administration prevents skin irritation, adhesion problems, and unwanted transference of androgen. Intranasal methods allow rapid delivery of TRT, culminating in only seconds of application per day. After a screening period for nasal inflammation, drug abuse, and prostate enlargement, hypogonadal males averaging 54.4 years of age engaged in TRT over the course of 90 days5. The experimental tests of transmucosal TRT gel show an increase to normalized levels of testosterone in 73 percent of the testing population. Out of 306 subjects, one man had a severe treatment-emergent adverse event of myalgia which did not warrant the discontinuation of the test drug. After the patients concluded the study, “nearly 70% subjects previously treated with another TRT said that they would be willing to switch to Natesto, suggesting that the multiple daily dosing was not a major inconvenience.” Thanks to gel based testosterones, patients can apply a TRT most adequate for their needs and continue to prevent low …show more content…
Researchers conducted a study of 149,354 men diagnosed with PC–including 1,181 men who received TRT4. Overall, TRT was not associated with PC deaths. Furthermore, researchers reported on 103 men who were treated with TRT after a prostatectomy. The trial showed no evidence of cancer resurgence after 3 years of investigation. These studies led researchers to hypothesize the therapeutic role of testosterone in prostate cancer.
Scientists are currently requesting additional study on the apoptosis of androgen-independent PC cells. The characteristics of the mutated prostatic cells would cease replication when exposed to testosterone-albumin complex, while allowing the prostatic membrane to remain intact. The increase in division of PC cells due to testosterone addition in mice has been observed. The theory of anti androgen application in PC has been theorized but not yet tested.