Temporal Lobe Epilepsy Is The Most Common Type Of Epilepsy Essay
Temporal lobe epilepsy is the most common type of epilepsy in adults, affecting approximately 1% of the general population. It is formally classified as neuronal misfiring in the mesial temporal lobes causing spontaneous, recurring seizures. In this review, I will investigate how the use of optogenetics in temporal lobe epilepsy (TLE) reduces seizures and how it can help us understand the cell types and neuronal circuits that underlie seizure generation. The significance of the review is due to the lack of specificity in current treatments and the prevalence of the drug-resistant variation of TLE. This review will focus on three parameters that emerge repeatedly throughout the literature: the methods used to decrease seizure frequency, duration, and activity. This review is organized as follows: Section 1 examines the current treatments of TLE and the major concerns with them; Section 2 includes a review of the literature, broken down into various commonalities; Section 3 investigates the evidence of opsins decreasing seizure frequency, duration, and activity; Section 4 discusses the limitations appearing in the literature.
Section 1: The Importance of Optogenetics in TLE
Before I begin the review of the literature, I will mention the current treatments of TLE and the problems that lie in the quest to finding a remedy. Explaining this will demonstrate the significance of implementing optogenetics into TLE and help increase the importance of why it is…