T cells also have effect on Natalizumab in patients with multiple sclerosis. Natalizumab is a monoclonal antibody that reduces the formation of acute lesions in the central nervous system. Bornsen et. al revealed the influence that natalizumab has on circulating CD4+ T cells in multiple sclerosis. The recurrence of multiple sclerosis happens when there are abnormalities in activated macrophages, CD4+ and CD8+ T cells in the central nervous system. Very-late antigen formed on surfaces of most immune system, binding to vascular cell adhesion molecule expressed on endothelial cells is important in the attachment and movement of activated macrophages, CD4+ and CD8+ T cells from the blood to the central nervous system. Also, the binding of Natalizumab antibody to VLA-4 (very- late antigen) which consist of a4 (CD49D) and b1 chain (CD29) helps in
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Natalizumab treated multiple sclerosis patients had greatly increased the formation of TNF and significantly decreased expression of IL10 in circulating CD4+ and CD8+ T cells which does not correlate between Expanded Disability Status Scale (EDSS) or the disease. Expanded Disability Status Scale (EDSS) is a method by which disability is determined in multiple sclerosis. Also, there were no contrast in the CD4+ T cell proliferation or expression of cytokine in untreated and multiple sclerosis patients treated with natalizumab and natalizumab had no serious effect on the part of proliferating CD4+ T cells or a formation of IL-17A and IFN-c in MBP-reactive CD3+ CD8 T cells. CD4+ and CD8+ T cells from patients treated with natalizumab shows levels of messenger RNA encoding TNF-a transcript. Effector T cells also have a high capacity in the production of pro-inflammatory cytokines and may result to a better pool of pro inflammatory
Natalizumab treated multiple sclerosis patients had greatly increased the formation of TNF and significantly decreased expression of IL10 in circulating CD4+ and CD8+ T cells which does not correlate between Expanded Disability Status Scale (EDSS) or the disease. Expanded Disability Status Scale (EDSS) is a method by which disability is determined in multiple sclerosis. Also, there were no contrast in the CD4+ T cell proliferation or expression of cytokine in untreated and multiple sclerosis patients treated with natalizumab and natalizumab had no serious effect on the part of proliferating CD4+ T cells or a formation of IL-17A and IFN-c in MBP-reactive CD3+ CD8 T cells. CD4+ and CD8+ T cells from patients treated with natalizumab shows levels of messenger RNA encoding TNF-a transcript. Effector T cells also have a high capacity in the production of pro-inflammatory cytokines and may result to a better pool of pro inflammatory