Targeting solid tumors - primary & metastatic - irrespective of their anatomical location in the body or pathological sub-type – and permeating drug molecules into the targeted tumor mass, will improve therapeutic outcomes and reduce life-threatening systemic toxicities induced by routinely administered chemotherapeutic regimens. Creating molecular dimension-specific temporary pores in the cell membrane using precisely computed, safe radiofrequencies (RF) from an external source, to non-invasively deliver the drug payload, is much less complicated and more cost-efficient than current or emerging invasive, drug delivery approaches. The short-comings of cancer chemotherapy plaguing the industry and patients that desperately need good drugs, can
…show more content…
Drug targeting of the chemotherapeutic molecules - carboplatin and paclitaxel during Cycle 2 through 6 and an additional Cycle 7, in a case of advanced, recurrent, metastatic, nasopharyngeal carcinoma (NPC) as part of a proof of concept pilot study, is reported. Systemic chemotherapy was enabled by the concurrent use of non-ionizing, safe radio-frequencies (RF) using specialized antennae in the presence of instantaneous magnetic resonance (MR). FORN is used to create temporary, drug molecular weight-specific nano-pores in the cell membrane of target …show more content…
Base-line chemotherapy induced adverse event evaluation, before applying FORN, and tumor response criteria based on PET-CT scans, were compared with chemotherapy cycles combined with the FORN protocol. Considering that most therapies offered in advanced stages of cancer offer little to no overall survival benefit, the use of a sophisticated yet safe, non-invasive RF and MR-mediated drug delivery technology like FORN, enhanced the therapeutic efficacy of cytotoxic chemotherapy; improved treatment outcomes; dramatically mitigated adverse systemic toxicities and improved Quality of Life (QoL) in this report of an NPC patient presenting with loco-regional recurrence and advanced, multiple
Drug targeting of the chemotherapeutic molecules - carboplatin and paclitaxel during Cycle 2 through 6 and an additional Cycle 7, in a case of advanced, recurrent, metastatic, nasopharyngeal carcinoma (NPC) as part of a proof of concept pilot study, is reported. Systemic chemotherapy was enabled by the concurrent use of non-ionizing, safe radio-frequencies (RF) using specialized antennae in the presence of instantaneous magnetic resonance (MR). FORN is used to create temporary, drug molecular weight-specific nano-pores in the cell membrane of target …show more content…
Base-line chemotherapy induced adverse event evaluation, before applying FORN, and tumor response criteria based on PET-CT scans, were compared with chemotherapy cycles combined with the FORN protocol. Considering that most therapies offered in advanced stages of cancer offer little to no overall survival benefit, the use of a sophisticated yet safe, non-invasive RF and MR-mediated drug delivery technology like FORN, enhanced the therapeutic efficacy of cytotoxic chemotherapy; improved treatment outcomes; dramatically mitigated adverse systemic toxicities and improved Quality of Life (QoL) in this report of an NPC patient presenting with loco-regional recurrence and advanced, multiple