Synthesis Of Ketamine

Ketamine exhibits a wide range of different molecular effects and targets and the search for major molecular adaptations that ultimately affect many forms of synaptic plasticity in mood-associated neuronal circuitry has been a convergent mechanism to explain its rapid efficacy.
Searching for new agents that can modulate the NMDA receptor complex and may be an effective approach to achieve rapid onset of antidepressant effects but with limited potential adverse effects. ketamine exerts rapid antidepressant-like effects by enhancing AMPA relative to NMDA throughput in critical neuronal circuits and targets. feedback mechanisms that control synaptic homoeostasis
Very few preclinical targets identified as relevant in preclinical studies became clinically relevant for drug discovery and even as predictive or surrogate biomarkers in subsequent initial clinical studies. …show more content…
This is consistent with the view of weak efficacy of other high affinity and low trapping NMDAr antagonists. Regarding potential implications to new therapeutics, besides the obvious need to perform additional studies in humans to confirm these exciting preclinical data, additional strategies could include the evaluation of alternative agents targeting other glutamate ionotropic receptors, especially