Symptoms And Potential Treatment Options Essay

1503 Words Nov 14th, 2016 7 Pages
Colloquially known as “brittle bone disease”, Osteogenesis imperfecta (OI) describes a group of genetic disorders estimated to affect around 7 out every 100,000 people around the world. As the name suggests the principal characteristic of osteogenesis imperfecta is the imperfect formation of the bones, i.e. increased bone fragility and lower bone mass, leading to frequent fractures or breaks from minor trauma (Rauch et al., 2004). Depending on the severity of symptoms the impact on an affected individual 's life can vary. This report will supply the necessary information for patients or those with family and loved ones afflicted with OI to manage and understand their condition, by focusing on the four main classifications of osteogenesis imperfecta and explanations for the causes, symptoms and potential treatment options.
Osteogenesis imperfecta is most frequently classified using a system developed by Sillence and colleagues, who confirmed there are at least “ four syndromes” known as osteogenesis imperfecta. Sillence places patients in four clinical categories (Type I, Type II, Type III and Type IV) based on expressed symptoms, the most important of which is the level of bone fragility (Sillence et al., 1979). Severity of bone fragility runs a touch out of order, but going from least fragile to most fragile is; Type I, Type IV, Type III and Type II. Sillence’s classification system also takes into account multiple extra-skeletal factors including the…

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