Abstract: Wisdom Panel’s genetic analysis of a canine with traits that are predominant in the animal shelter supports that Sunny is a mixed breed with terrier blood on both sides of her ancestry tree. This did not support that her breed would have relatively higher susceptibility to mutations as she tested negative for MDR1, and also displays no lameness, behavior, or traits limiting her mobility and neurological state.
Introduction: In shelters, there are predominantly medium to large dark-coated dogs who are likely to remain at the shelter twice the length of smaller breeds. A client who adopted a medium dark brown dog, Sunny, sought breed identification to determine Sunny’s genotype for a health-monitoring program within stray dogs allocated …show more content…
Sunny displayed phenotype and behavioral similarities with the malinois which includes having a squared stance, pricked ears, agility, and also has good watchdog qualities by being alert- all comparable to terrier traits. Sunny has small residual white on her chest, indicating that it is not normal piebald pattern but is caused from pigment not fully migrating as an embryo. This denoted a risk of mutations which L. Andersson refers to In Genome-wide association analysis in domestic animals, regarding white spotting due to varying combinations of mutations that ultimately affect MITF expression. MITF regulates melanocyte, and mutations of this gene are associated with severe pleiotropic effects targeting hearing and vision. However, Sunny’s alert behavior has shown no disabilities from MITF mutation. A small fraction of Shetland sheepdog accounts for the absence of her herding abilities, and also tested negative for a multidrug resistance mutation, MDR1, which are predominant in herding breeds. Her pricked ears resemble those of the Boston terrier and her tail is similar to the Staffordshire terrier. Significant presence of Chow Chow was surprising in that Sunny does not present dominant traits of a chow, nor has she shown susceptibility to canine hip
Introduction: In shelters, there are predominantly medium to large dark-coated dogs who are likely to remain at the shelter twice the length of smaller breeds. A client who adopted a medium dark brown dog, Sunny, sought breed identification to determine Sunny’s genotype for a health-monitoring program within stray dogs allocated …show more content…
Sunny displayed phenotype and behavioral similarities with the malinois which includes having a squared stance, pricked ears, agility, and also has good watchdog qualities by being alert- all comparable to terrier traits. Sunny has small residual white on her chest, indicating that it is not normal piebald pattern but is caused from pigment not fully migrating as an embryo. This denoted a risk of mutations which L. Andersson refers to In Genome-wide association analysis in domestic animals, regarding white spotting due to varying combinations of mutations that ultimately affect MITF expression. MITF regulates melanocyte, and mutations of this gene are associated with severe pleiotropic effects targeting hearing and vision. However, Sunny’s alert behavior has shown no disabilities from MITF mutation. A small fraction of Shetland sheepdog accounts for the absence of her herding abilities, and also tested negative for a multidrug resistance mutation, MDR1, which are predominant in herding breeds. Her pricked ears resemble those of the Boston terrier and her tail is similar to the Staffordshire terrier. Significant presence of Chow Chow was surprising in that Sunny does not present dominant traits of a chow, nor has she shown susceptibility to canine hip