Charbill Klayme 0993551
Dr. Hye-Jeong Yeo
Functions of SREBPs Abstract
SREBPs are 1,150 Amino Acid long proteins that are used to activate cholesterolgenesis. SREBP-1a are used to induce all the response genes. The SREBP-2 are used to allow expression of the LDL receptor. Ubiquination, usually by the kinase GSK3, can be the weapon to destructing SREBPs. SREBP-1a will build more cholesterol and fatty acids in rats and mice when it is over expressed. The SREBP-1c are best studied in the liver when they affect when insulin is supposed to be initiated for hormonal activity within the blood.
Introduction
SREBPs, or Sterol Response Element Binding Proteins, are a sub-class of lipids that act as transcriptional co-activators. They are used …show more content…
They also can relate their activities to how messages and genes are found in RNAs (Osborne, 2000). As Miserez, Cao, Probst, and Hobbs have found together, two promoters can be found from the SREBP-1 gene (as cited in Osborne, 2000). Each of the two promoters can transcribe an mrna that has to code a different amino terminus (Osborne, 2000). As a result, protein encoding information of the both isoforms are the same sequence because they are located in the same ORF (open reading frame) (Osborne, 2000). In terms of activating gene expression, the SREBP-1a has a large amount of acidic amino acids to make it become a significant transcriptional activation area inside the longer N-terminal region (Osborne, 2000). Yet the SREBP-1c is not as effective for activating gene expression because it lacks so much more acidic amino acids (Osborne, 2000). Naar, Beauring, Zhou, Abraham, Solomon, and Tijan had together observed another alternate way of transcription for SREBP-1a (as cited in Osborne, 2000). They observed that it’s N-terminal domain will attach and bind to DRIP (Vitamin D receptor-interacting protein) to make a complex that will increase transcription when it interacts with activation domains of random transcriptional regulatory proteins (Osborne, 2000). In terms of …show more content…
J. (2006). SREBPs: sterol-regulated transcription factors. Journal of Cell Science, 119, 973-976. doi: 10.1242/jcs.02866
Osborne, T. F. (2000). Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 32379-32382. doi:10.1074/jbc.R000017200
Yeo, H. (2014). Fatty acid synthesis and regulation (II) [PowerPoint slides]. Retrieved from
Dr. Hye-Jeong Yeo
Functions of SREBPs Abstract
SREBPs are 1,150 Amino Acid long proteins that are used to activate cholesterolgenesis. SREBP-1a are used to induce all the response genes. The SREBP-2 are used to allow expression of the LDL receptor. Ubiquination, usually by the kinase GSK3, can be the weapon to destructing SREBPs. SREBP-1a will build more cholesterol and fatty acids in rats and mice when it is over expressed. The SREBP-1c are best studied in the liver when they affect when insulin is supposed to be initiated for hormonal activity within the blood.
Introduction
SREBPs, or Sterol Response Element Binding Proteins, are a sub-class of lipids that act as transcriptional co-activators. They are used …show more content…
They also can relate their activities to how messages and genes are found in RNAs (Osborne, 2000). As Miserez, Cao, Probst, and Hobbs have found together, two promoters can be found from the SREBP-1 gene (as cited in Osborne, 2000). Each of the two promoters can transcribe an mrna that has to code a different amino terminus (Osborne, 2000). As a result, protein encoding information of the both isoforms are the same sequence because they are located in the same ORF (open reading frame) (Osborne, 2000). In terms of activating gene expression, the SREBP-1a has a large amount of acidic amino acids to make it become a significant transcriptional activation area inside the longer N-terminal region (Osborne, 2000). Yet the SREBP-1c is not as effective for activating gene expression because it lacks so much more acidic amino acids (Osborne, 2000). Naar, Beauring, Zhou, Abraham, Solomon, and Tijan had together observed another alternate way of transcription for SREBP-1a (as cited in Osborne, 2000). They observed that it’s N-terminal domain will attach and bind to DRIP (Vitamin D receptor-interacting protein) to make a complex that will increase transcription when it interacts with activation domains of random transcriptional regulatory proteins (Osborne, 2000). In terms of …show more content…
J. (2006). SREBPs: sterol-regulated transcription factors. Journal of Cell Science, 119, 973-976. doi: 10.1242/jcs.02866
Osborne, T. F. (2000). Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action. THE JOURNAL OF BIOLOGICAL CHEMISTRY, 275, 32379-32382. doi:10.1074/jbc.R000017200
Yeo, H. (2014). Fatty acid synthesis and regulation (II) [PowerPoint slides]. Retrieved from