Sprague Dawley Rats

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Pure-bred Sprague Dawley rats (brown laboratory rats) are to be used in this experiment. These rats are preferred due to known calmness and ease of handling. To reduce variability, rats of the same weight, age, and gender will be chosen. Thirty-seven ADHD rats and thirty-seven non-ADHD rats will be chosen. This provides a sample size large enough to produce statistically significant values. Because there is no physical biological marker for rats with ADHD, behavioral symptoms must be observed to verify ADHD within that group. Variables that can be measured under statistical analysis are behavioral activity (wheel running) and measure of sustained attention. There are links between voluntary wheel running and rats with ADHD [1] and attention will be measured using the 5-choice serial reaction time test (5-CSRTT) developed by Carli and associates [2]. …show more content…
Water is to be present at all times and the same amount food to be given to each rat twice daily at the same time, to reduce variability.
The next step will be to ensure that all of the rats begin with a regulated circadian cycle, thus a 12:12 light-dark (LD) photo training will be imposed. The initial 5–7 days are to be used for acclimation. This LD cycle will be used for the duration of the experiment as a source to later confirm that Ritalin is causing disrupted circadian rhythms, not varying light cycles. Circadian rhythms will be measured by using a wheel-running activity first applied by Michael Verwey’s team [3]. Daily wheel running recordings will provide information about superchiasmatic nucleus (SCN)

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