Wang et al. (2015) formulated a solid dispersion to improve the solubility and bioavailability of Ginkgo biloba extract (GE) through hot melt technology. The polymer studied were Kollidon® VA64/Kolliphor® RH40 (85:15) and the extrusion was carried out at 120-125⁰C with 100 RPM with 25% drug load. DSC and XRD studies confirmed the amorphous conversion of the GE and the dissolution carried in 250ml of 0.1N HCl showed that the dissolution of solid dispersion of GE was significantly improved (2-3 folds at the end of 120 min) and much faster compared to pure GE and physical mixture.
Similarly Fu et al. (2016) prepared an amorphous solid dispersion of Nisoldipine (M.P 151⁰C) using Kollidon VA64 (at an extrusion temperature of 153⁰C ) in the …show more content…
The uniqueness of this kind of formulations is the absence of interactions between drug and carrier which makes the system thermodynamically stable in which the drug is suspended in a molten form in solid hydrophilic carrier with enhanced solubility. This is a kind of non-conventional system with reduced API size and its dispersion in hydrophilic polymer improving rate of dissolution of the API. TAKE REF FROM ARTICLE. Pawar et al. (2017) developed a solid crystalline suspension of poorly soluble Efavirenz (M.P 139⁰C) employing xylitol and pearlitol as crystalline carriers. Extrusion was carried at melting point (138-140⁰C) of Efavirenz with screw speed of 100 RPM. DSC and XRD studies confirmed the crystallinity of the formulations and FTIR chemical imaging confirmed the uniform distribution of API in hydrophilic carrier. The dissolution studies carried in 1000ml of 0.1N HCl with 0.2% SLS showed significant improvement in drug release (more than 90% in 1h) which is approximately 4 folds to the dissolution of pure drug in formulations with Xylitol (20 and 50 % drug load). Mannitol based formulations showed more than 80% in 1h in both drug loads. Irrespective of the nature of the polyols the drug release was improved by the hydrophilic environment provided by the crystalline carrier. Stability studies conducted up to 12 months showed no significant difference in the drug release pattern of mannitol based formulations but xylitol based formulations were
Similarly Fu et al. (2016) prepared an amorphous solid dispersion of Nisoldipine (M.P 151⁰C) using Kollidon VA64 (at an extrusion temperature of 153⁰C ) in the …show more content…
The uniqueness of this kind of formulations is the absence of interactions between drug and carrier which makes the system thermodynamically stable in which the drug is suspended in a molten form in solid hydrophilic carrier with enhanced solubility. This is a kind of non-conventional system with reduced API size and its dispersion in hydrophilic polymer improving rate of dissolution of the API. TAKE REF FROM ARTICLE. Pawar et al. (2017) developed a solid crystalline suspension of poorly soluble Efavirenz (M.P 139⁰C) employing xylitol and pearlitol as crystalline carriers. Extrusion was carried at melting point (138-140⁰C) of Efavirenz with screw speed of 100 RPM. DSC and XRD studies confirmed the crystallinity of the formulations and FTIR chemical imaging confirmed the uniform distribution of API in hydrophilic carrier. The dissolution studies carried in 1000ml of 0.1N HCl with 0.2% SLS showed significant improvement in drug release (more than 90% in 1h) which is approximately 4 folds to the dissolution of pure drug in formulations with Xylitol (20 and 50 % drug load). Mannitol based formulations showed more than 80% in 1h in both drug loads. Irrespective of the nature of the polyols the drug release was improved by the hydrophilic environment provided by the crystalline carrier. Stability studies conducted up to 12 months showed no significant difference in the drug release pattern of mannitol based formulations but xylitol based formulations were