Seum Urea Concentration Lab Report

Result and Discussion The concentration of serum alanine aminotransferase (ALT)(IU/L), aspartate amino-transferase (AST)( IU/L), Alkaline Phosphatase (ALP)(U/L), Serum creatinine (mg/dl), Serum albumin concentration (g\dl), Serum urea concentration (mg/dl) in all subjects were clarified in the table and figure (1). Depending on the result in the table , a significant (P0.05) differences in mean values of serum urea concentration in all Volunteers. The liver is the most important organ, which play a pivotal role in regulation of various physiological processes in the body. It is involved in several vital functions, such as metabolism, secretion and storage. It has great capacity to detoxicate toxic substances and synthesized useful principle (10) .When liver cell membrane is damaged a variety of enzymes located normally in cytosol is released into the blood, thereby, causing an increase in the level of ALT, AST, and ALP (11, 12). The …show more content…
One of these mechanism , oxidative stress, which disturbs the antioxidant defense system and produces reactive oxygen species (ROS), including hydrogen peroxide, superoxide, and hydroxyl radicals (13, 14).Benzene and related hydrocarbons are metabolized through an intermediate epoxide, which is highly reactive and possibly binds to hepatic microsomal proteins and nucleic acids leading to cytotoxic effects (15). An increase in the levels of liver diagnostic parameters in this study might be due to toxic effect on the membrane of liver cell where petroleum hydrocarbons may have been converted into free radicals or activated metabolites during their oxidation (16) .Also, it has been observed that there were degenerative changes in renal and hepatic functions after exposing rats to light and heavy petrol (17) . An increase of serum creatinine in subjects exposed to gasoline vapor indicate renal pathology, and confirm the result of Bartimaeus and Jacobs (18)