Essay about Sepsis: Inflammation and White Cell Count
Mr. Jones clinical assessment revealed that his Glasgow Coma Score was 11/15. He was opening his eyes to speech, only making inappropriate words and localizes to pain. He was also pyrexial with a temperature of 39.0 ˚C, diaphoretic with hot peripheries, hypotensive BP 90/45 mmHg (MAP 60 mmHg), and tachyopneic at 30breaths/min and …show more content…
In addition, sepsis causes enhanced coagulation with stimulation of the coagulation cascade. This produces a reduction a reduction in the level of protein C and antithrombin III which results in the formation of micro emboli, further impairing blood flow and organ perfusion (Porth, 2005). Inflammatory mediators cause activation of intrinsic and extrinsic clotting pathways. Thrombosis, intravascular fibrin deposits and bleeding develop. Inhibitory pathways of protein C and Protein S are impaired and depleted and clotting increases in plasminogen activator inhibitor levels. Coagulation factors are depleted, and bleeding worsens. Disseminated intravascular coagulation (DIC) may result (Munford, 2001).
The three major effects of septic shock within the vascular system are vasodilation, maldistribution of blood volume and