Consanguineous Marriages
In South India
Consanguineous marriages are known as blood related marriages. Mostly these marriages are between cousins of maternal or paternal side and also in between uncle & neice.
Consanguineous marriages are favourable only with cross-cousins, but not with parallel-cousins.
Cross-cousins: child of the father's sister(paternal aunt's child) child of the mother's brother(maternal uncle's child)
Parallel-cousins: child of father's brother(paternal uncle's child) child of mother's sister(maternal aunt's child)
Around the world consanguineous marriages have been practiced by many societies, it is all about there culture and customs they believe in. It is widely …show more content…
Consanguineous marriages are major responsible risk factors for Bipolar disorders. This marriage system has been reported as an important factor in the appearance of autosomal recessive diseases and congenital anomalies, including hydrocephalus, postaxial hand polydactyly and bilateral cleft lip cleft palate, bipolar disorders, depression, dysferlinopathy, reproductive disorders, sterility, infant mortality, child deaths, spontaneous abortions and stillbirths etc. Also there are reports indicating positive association between consanguinity and Down syndrome, and also ventricular septal defect (VSD), atrial septal defect (ASD), atrioventricular septal defect (AVSD), pulmonary stenosis (PS) and pulmonary atresia (PA). The risk for birth defects in the offspring of first cousin matings has been increased to 5-8% compared to 2-3% in non-consanguineous marriages. The phenomenon of inbreeding increases the level of homozygotes for autosomal genetic disorders and leads to a low biological fitness of a population known as inbreeding depression. The offspring of consanguineous couples are at greater risk of certain genetic disorders. Autosomal recessive disorders occur in individuals who are homozygous for a particular recessive gene mutation, it means they carry two copies of the same gene. Only in exceptional certain cases both the parents of an individual with such a disorder will be carrying the gene. Such carriers are not affected and will not display any signs that they are carriers, and so may be unaware that they carry the mutated gene. As relatives share a proportion of their genes, it is much more likely that the related parents will be carriers of an autosomal recessive gene, and therefore their children are at a higher risk of an autosomal recessive disorder. Extent to which the risk increases depends on the degree of genetic relationship between the
In South India
Consanguineous marriages are known as blood related marriages. Mostly these marriages are between cousins of maternal or paternal side and also in between uncle & neice.
Consanguineous marriages are favourable only with cross-cousins, but not with parallel-cousins.
Cross-cousins: child of the father's sister(paternal aunt's child) child of the mother's brother(maternal uncle's child)
Parallel-cousins: child of father's brother(paternal uncle's child) child of mother's sister(maternal aunt's child)
Around the world consanguineous marriages have been practiced by many societies, it is all about there culture and customs they believe in. It is widely …show more content…
Consanguineous marriages are major responsible risk factors for Bipolar disorders. This marriage system has been reported as an important factor in the appearance of autosomal recessive diseases and congenital anomalies, including hydrocephalus, postaxial hand polydactyly and bilateral cleft lip cleft palate, bipolar disorders, depression, dysferlinopathy, reproductive disorders, sterility, infant mortality, child deaths, spontaneous abortions and stillbirths etc. Also there are reports indicating positive association between consanguinity and Down syndrome, and also ventricular septal defect (VSD), atrial septal defect (ASD), atrioventricular septal defect (AVSD), pulmonary stenosis (PS) and pulmonary atresia (PA). The risk for birth defects in the offspring of first cousin matings has been increased to 5-8% compared to 2-3% in non-consanguineous marriages. The phenomenon of inbreeding increases the level of homozygotes for autosomal genetic disorders and leads to a low biological fitness of a population known as inbreeding depression. The offspring of consanguineous couples are at greater risk of certain genetic disorders. Autosomal recessive disorders occur in individuals who are homozygous for a particular recessive gene mutation, it means they carry two copies of the same gene. Only in exceptional certain cases both the parents of an individual with such a disorder will be carrying the gene. Such carriers are not affected and will not display any signs that they are carriers, and so may be unaware that they carry the mutated gene. As relatives share a proportion of their genes, it is much more likely that the related parents will be carriers of an autosomal recessive gene, and therefore their children are at a higher risk of an autosomal recessive disorder. Extent to which the risk increases depends on the degree of genetic relationship between the