Rett syndrome is a rare X-linked neurodevelopment disorder. Mutations in X linked gene methyl CpG binding protein 2 (MeCP2) underlie most cases of Rett Syndrome, which causes severe cognitive impairment in females and some males at a very young age. Research from MecP2 null mice models of Rett Syndrome reveals disabilities in the Hippocampus region of the brain showing significant alterations in the behavior, motor function and locomotion activity. Existing data from electrophysiology and western blot analysis show severe changes in protein expression, synaptic plasticity, long-term potentiation and long-term depression. In our study, we assess the role of specific synaptic proteins in a MeCP2 KO rat model of Rett Syndrome, to compare the data
