Resistance To Insulin Essay

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Insulin, one of the most important peptide hormone in the body, which plays significant role in maintaining the blood glucose level in the body. Under certain physiological conditions such as pregnancy, the body mechanism changes due to elevated levels of certain secretory factor like leptin, plasminogen activator inhibitor-1, TNF-α, plasminogen activator and testosterone (McLachlan et al., 2006), which produces certain adverse effects, insulin resistance being the most prominent one, where the body fails to utilize insulin leading to complications like, gestational diabetes mellitus, preeclampsia and gestational hypertension (Thadani et al., 2004). Also, during gestation, combinatorial effects of hormones like, human placental lactogen (Brelje et al., 1993), progesterone (Kalkhoff et al., 1970), estradiol and cortisol, act as counter-regulatory hormones to insulin, which contributes to more resistance of the body towards insulin (Ryan et al., 1988). …show more content…
Hence, understanding the role of insulin in wide-ranging physiological processes, pregnancy specifically and the influences on its synthesis and secretion, alongside its actions from the molecular to the whole-body level, has its own significant implications for several chronic diseases. Hence, an overall review on the impact of insulin resistance on Pregnancy is done in this research paper to focus on the aspects that causes the resistance of insulin as well as various physiological consequences as an outcome to this

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