Research Study On Human Genes And Expression Patterns Essay
Reason to Research: To understand the causes of CL/P. In this study researchers show the results of sequencing 20 different genes in 186 CL/P cases. The cases that were selected were cases where the family had a positive history for CL/P and an emphasis was placed on cases were the phenotype was more severe.
Materials and Methods: CL/P cases were collected from two different locations. 93 were selected from Iowa, United States and 91 cases were selected from the Philippines. These were used to search for mutations in 20 candidate genes.
Scientists selected the more-severe cases that was available to them. Sequenced samples were enriched by bilateral cleft lip and palate cases with a positive family…