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Discovery/History
Evidence supports that the disease has been around since ancient times.The earliest case of OI was recorded to be about 1,000 …show more content…
Most cases of babies born with OI are in families without a history of having the condition. The dominant inheritance of the gene can alter the normal gene in two way. The first way it does this is by altering the collagen gene doing this by even the slightest manner causes type II, III, and IV of OI. The second way it does this is by failing to direct the genes which produce collagen causing type I of OI. The difference in the dominant genes is that the first affects the quality of the collagen while the second affects the quantity of the collagen. It is less common when someone is affected by OI from the recessive trait. When the parents of a child autosomal recessive disorder they do not have the disorder, but are carriers of it.The only way a child will receive the disorder is if they receive two copies of the altered genes. When two carriers of the recessive trait of OI have children, each child has a 25% chance to be affected, a 50% chance to be a carrier, and a 25% chance to be unaffected and also not be a carrier. There are eight known types of OI which are labeled I through VII. These are recognized through their symptoms and characteristics. The most mild form of OI is type