Replication Inhibitors

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Replication Inhibitors

Replication inhibitors interfere with DNA synthesis. There are many of these inhibitors, but they typically work via two main mechanisms. One of these mechanisms involves either disrupting molecules that are needed for DNA polymerization or those needed in order to initiate replication. The other mechanism is by interfering with replication checkpoints that are involved in regulating the replication process. These checkpoints sometimes do this by triggering certain events such as cell death or DNA repairs. The main application of replication inhibitors is their use as anticancer or antiviral drugs that are underlined by problems in DNA replication. Daunorubicin hinders topoisomerase activity by stabilizing

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