〖Na〗^+and K^+channel relationship
Figure one shows the temporal relationship between 〖Na〗^+ conductance (g_Na) and K^+ conductance (g_(K )), and the relative changes in the V_m during an action potential. 〖 g〗_Na increased as the V_m moved towards 0 mV causing depolarization of the membrane and started to decrease immediately after the peak of the action potential. Whereas, g_(K ) increased immediately following the action potential peak during the repolarization of the plasma membrane where the V_m moved away from 0 mV and became negative (Figure 1).
Pharmacological Inhibition
Figure two shows the effect of increased concentration of STX on the ion channels during an action potential. The depolarization slope in the action potential became less steep as the concentration of STX increased. Likewise, the slope of repolarization decreased as STX …show more content…
The overall amplitude of action potential decreased as the concentration ratio of 〖Na〗^+ decreased. Lowest amplitude was observed when the 〖Na〗^+ concentration ratio was set at 0.1 and the highest amplitude was observed when the 〖Na〗^+ concentration ratio was set at 1. The depolarization and repolarization slopes along with g_Na and g_K decreased as the 〖Na〗^+ concentration ratio approached 0mV (Figure 4).
Figure five shows how altering E_K through ion substitution changes g_x of ions involved in an action potential. The depolarization slope of the action potential remained unaffected by the change in the K^+ concentration ratio. The repolarization slope became less steep as the K^+ concentration ratio was moving further away from 1. When the K^+ concentration ratio was at 33 the repolarization slope greatly decreased. Additionally, the g_(K )decreased as the K^+ concentration ratio value increased, whereas, the g_Na remained unchanged (Figure
Figure one shows the temporal relationship between 〖Na〗^+ conductance (g_Na) and K^+ conductance (g_(K )), and the relative changes in the V_m during an action potential. 〖 g〗_Na increased as the V_m moved towards 0 mV causing depolarization of the membrane and started to decrease immediately after the peak of the action potential. Whereas, g_(K ) increased immediately following the action potential peak during the repolarization of the plasma membrane where the V_m moved away from 0 mV and became negative (Figure 1).
Pharmacological Inhibition
Figure two shows the effect of increased concentration of STX on the ion channels during an action potential. The depolarization slope in the action potential became less steep as the concentration of STX increased. Likewise, the slope of repolarization decreased as STX …show more content…
The overall amplitude of action potential decreased as the concentration ratio of 〖Na〗^+ decreased. Lowest amplitude was observed when the 〖Na〗^+ concentration ratio was set at 0.1 and the highest amplitude was observed when the 〖Na〗^+ concentration ratio was set at 1. The depolarization and repolarization slopes along with g_Na and g_K decreased as the 〖Na〗^+ concentration ratio approached 0mV (Figure 4).
Figure five shows how altering E_K through ion substitution changes g_x of ions involved in an action potential. The depolarization slope of the action potential remained unaffected by the change in the K^+ concentration ratio. The repolarization slope became less steep as the K^+ concentration ratio was moving further away from 1. When the K^+ concentration ratio was at 33 the repolarization slope greatly decreased. Additionally, the g_(K )decreased as the K^+ concentration ratio value increased, whereas, the g_Na remained unchanged (Figure