Lysyl Trna Synthetase Research Paper

Ryan Schoen
Mrs. Lily Gu
Protein Project - function
October 20, 2014

Lysyl-tRNA Synthetase

Lysyl-tRNA Synthetase has a couple known names, one of them being aminocyl tRNA. The major role of this protein is translation during protein synthesis. For a protein to be classified and placed into an amino acid group, its amino acid sequence must be properly translated. Transfer RNA helps translate the protein which helps with genetics. Aminoacyl tRNA synthetases are the enzymes that are responsible for the specific aminoacylation of tRNA (Yifat, 2013). Let’s take a more in depth look at the function of this protein by breaking it down.
Lysyl, otherwise known as lysyl oxidase, is synthesized as a preproprotein, meaning it contains a nonpolar signal
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It attaches itself to a dinucleotide found in the cytoplasm, which then interacts with the protein AIMP2, which has a distinct effect on white blood cells (Yang, 2013). Each cell in the human body has what’s called macrophages. These macrophages work with white blood cells. They are known as the clean-up crew that goes around eating most of the bacteria and other junk that gets left behind.
Lysyl-tRNA synthetase binds to transcription factors, which can lead to allergies. It also may be a target of autoantibodies, which can lead to disease (Smith, 1998). Lysyl-tRNA synthetase is also involved in the signaling pathway, which has a direct connection to the genes in the DNA of a person.
Lysyl-tRNA Synthetase has some important rules. It is important for protein synthesis, helps regulate signal molecules, and an important activator of a person’s genes in their DNA. Lysyl-tRNA Synthetase will continue to be studied for years to come and I am curious as to what more information scientists will find about
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(1995). Solution Structure of the Anticodon-binding Domain of Escherichia coli Lysyl-tRNA Synthetase and Studies of its Interaction with tRNA^Lys. JMB, 253, 100-113.

Smith, Mungo, Kagan, HM. (1998). LLysyl oxidase: properties, regulation and multiple functions in biology. Boston University School of Medicine, (7), 387-398.

Yang, Xiang-Lei. (2013). Structural disorder in expanding the ‘functiome’ of aminoacyl-tRNA synthetases. US National Library of Medicine National Institutes of Health, (9), 1093-1099. doi: 10.1016/j.chembiol.2013.07.013

Yifat Ofir-Birin, Pengfei Fang, Steven P. Bennett, Jing Wang. (2013). Structural Switch of Lysyl-tRNA Synthetase between Translation and Transcription. Molecular Cell, 49 (1), 30-42. DOI: 10.1016/j.molcel.2012.10.010

2014. Transfer RNA/tRNA. Retrieved from

2014. Biology online. Retrieved from

2014. Biology online. Retrieved from

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