Protein And The Amino Acids Essay

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A protein has a precisely defined amino acid sequence which gives rise to its three dimensional structure which is essential to the protein’s function. These amino acids interact with one another to produce a specific folding pattern that produces the conformation of the protein. When one looks at the progression a protein makes in its folding complexity, it is clear that the folding is driven by the amino acid sequence alone.
To understand this concept it is best to start with the primary structure of the protein, the polypeptide chain. The first interaction the amino acids make, a peptide bound, is the first instance where protein folding is directed. Two amino acids are joined together through a condensation reaction producing a peptide bond. There are many characteristics of this peptide bond that contribute to the overall three dimensional structure of the protein. First, the bond is planar with three atoms lying on the same plane. This planar characteristic of the peptide bond restricts possible folding options for the protein. Second, the bond is uncharged and this lack of repulsion allows amino acids to form tightly packed globular structures. Steric hindrances between the R groups of amino acids also contribute to the proteins final folding pattern. Even though there are single bonds capable of free rotation in each amino acid, the steric interactions of the R groups restrict the angles available to them (Tymoczo, Berg, & Stryer, 2013). The nature of…

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