Christina McNellis Contemporary electrotherapy HND Beauty Therapy Unit DP3F 35 Microdermabrasion Type of treatment In microdermabrasion, tiny crystals are sprayed onto the skin to gently remove the outer layer of your skin. This technique is less aggressive than dermabrasion, so you don't need numbing medicine. It is an exfoliation and skin rejuvenation procedure that leaves skin looking softer and brighter…
The citric acid cycle produces energy by the oxidation of acetyl coenzyme A (acetyl CoA) to carbon dioxide (CO2) and ATP 3, 5, 7. Acetyl CoA can be synthesised from carbohydrates, fatty acids and amino acids.1, 5, 7. Pyruvate produced in glycolysis undergoes oxidation and decarboxylation by the multi enzyme complex pyruvate dehydrogenase to produce acetyl CoA. 7, 8, 10. The citric acid cycle also provides carbon skeletons for the biosynthesis of amino acids, fatty acids, carbohydrates, cholesterol, haeme and other molecules that are vital for survival. 1, 5, 6,…
During the first step of the payoff phase, glyceraldehyde-3-phosphate which was produced during the preparatory phase, is oxidised and phosphorylated to 1,3-bisphosphoglycerate (1,3-BGP) to produce 2 NADH molecules and 2 protons. This occurs through glyceraldehyde-3-phosphate dehydrogenase. With the help of magnesium and phosphoglycerate kinase, 1,3-bisphosphoglycerate is changed to 3-phosphoglycerate, which frees up an ATP molecule. An ATP molecule is released in step 10 when phosphoenolpyruvate, through pyruvate kinase, magnesium and potassium ions produce pyruvate. Overall, a net production of 2 pyruvate molecules, two NADH molecules and two molecules of ATP occur for every molecule of…
The effects of gene mutation on Olfactory Sensory Neurons in Caenorhabditis Elegans Amira Brown University of California, Santa Barbara Abstract This experiment examines the effects of distinct odorants on chemotaxis behavior of the nematode worm, Caenorhabditis elegans (C. Elegans). Nematode worms are appropriate for sensory physiology studies because its neuronal wiring is similar to that of humans. We focused on the role of three sensory neurons in the nose of the nematode—the 1) AWA and 2)…
The 1H NMR data strongly suggests that 3-pentanol was produced. On the 1H NMR, there are a total of 12H, which is the correct number of protons on 3-pentanol. Around 3.45ppm, there is a multiplet with an integration of 1. This peak corresponds to the methine proton on the carbon bearing the alcohol. The integration of 1 is correct since there is only one proton on that carbon.…
Chemical Aspects of Digestion Lab Report By Abdulelah Almutairi Animal Form and Function Lab, 03, 12:30 PM Instructor: Melanie Gustafso-Ropski – Lab Assistant: Corinna Monday March 9,2015 1. Part A • The enzyme used in this experiment is pancreatic lipase. The substrate for pancreatic lipase is lipids or triglycerides.…
Since leukotrienes have a major impact on asthma, researchers then began questioning where they were derived from. Leukotrienes are formed from omega 6 vegetable oil, which is also known as linoliec acid. Researchers have discovered that the way we eat is one of the major causes of asthma and allergic reactions. Eicasonoids generated from PUFA, particularly omega 6 are some of the early substances released in the lungs during an asthma attack. Omega 6, however, is not the only substance that can exacerbate asthma.…
In this lab, we carried out a variety of reactions using different chemicals and metals. A chemical reaction is when the chemical state of the substance you are testing rearranges its ionic and molecular structure. One of the reactions we experienced was single replacement, this consists of one ion switching places with another ion to form a new compound. Another reaction we saw was double replacement. In this reaction, two compounds ions are switched to form two new compounds.…
ABSTRACT: Profitable animal production require high fertility animals that exhibit healthy ovarian follicles, which contributes to estradiol synthesis. Follicle maturation relies on coordination between pituitary hormones and intraovarian signaling pathways. Recently Wnt/beta-catenin signaling has been established as necessary modulators of folliculogenesis in response to FSH. In granulosa cells (GC), beta-catenin is a central key in regulation of aromatase (Cyp19a1) expression. In addition, protein kinase A (PKA) but not protein kinase B (AKT) phosphorylation of beta-catenin results in regulation of FSH target genes.…
Parturition involves many physiological and hormonal changes in which prostaglandin plays a critical role. The release of cortisol initiates parturition process by down-regulating progesterone, which ends the uterine quiescence. Cortisol enhances estrogen receptors’ expression, which makes uterine more sensitive to other uterotonic agents. Estrogen causes myometrial contractions, which will trigger the hypothalamus to release oxytocin hormone. Oxytocin will also cause uterine contractions and enhances prostaglandin synthesis.…
1.5 Drugs targeting the Rab prenylation pathway 1.5.1 Prenylation pathway Prenylation of Rab proteins is the essential lipid modification step that begins the membrane trafficking cycle. It is a crucial post-translational modification that allows the stable attachment of Rab proteins to the membrane by increasing hydrophobicity to be able to insert into the lipid bilayer (Maltese, Wilson and Erdman, 1996). As depicted in Figure 7, the Rab cycle starts with a Rab protein that is GDP bound, in its inactive state. It binds to Rab escort protein (REP), which directs it to the RGGT, where the Rab protein is isoprenylated by addition of geranylgeranyl pyrophosphate (GPP) group or farnesyl pyrophosphate (FPP) onto the cysteine.…
Our logic for choosing kinesin for developing CNS therapeutics is based upon our own research, which found that kinesins are transcriptionally upregulated during memory storage and that they are both necessary and sufficient to induce long-term memory storage (LTM) in the marine snail, Aplysia californica (Puthanveettil et al., 2008; Fig 1). Furthermore, other researchers have also discovered that an increase in specific kinesin function in the mouse forebrain improves working memory (Wong et al., 2002; Fig 1). Kinesin is also important in mediating cell division and thus this specific function has been explored for tumor growth inhibition in the development of cancer therapeutics (e.g. Song et al., 2013). These efforts have led to the development of kinesin inhibitors, though none has…
It is formed by the removal of water from two ethanoic acid molecules. Because acetic anhydride is the second most reactive carboxylic acid derivative, they can be readily converted into other less reactive carboxylic acid…
Abstract: The objective of this experiment was to synthesize aspirin from salicylic acid and acetic anhydride. The general theory behind this experiment was to study the synthesis of a drug from organic materials. During the experiment, esterification had occurred between reactants salicylic acid and acetic anhydride. Then, phosphoric acid would catalyze the reaction and water would be added to decompose the remaining acetic anhydride. Through the process of filtration, aspirin crystals were collected and separate from the liquid acetic acid-water solution.…
Introduction Stereochemistry alludes to the science that reviews the properties of stereoisomers. It can likewise be characterized as the branch of chemistry concerned about the three-dimensional course of action of particles and atoms and the impact of this on concoction responses. A critical branch of stereochemistry is the investigation of chiral atoms. Stereochemistry is otherwise called 3D science in light of the fact that the prefix "stereo-" signifies "three-dimensionality". The primary investigation of stereochemistry is on stereoisomers and traverses the whole range of natural, inorganic, organic, physical and particularly supramolecular science.…