Pros And Cons Of Leucovorin

Fluorouracil FDA pregnancy category X which means that studies in animals or humans beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of use of the drug in pregnant women clearly outweighs any possible benefit. It is unknown whether or not fluorouracil crosses the placenta. Leucovorin is a Pregnancy category C which indicates that studies have revealed adverse effects on the fetus and there are no controlled studies in women or studies in women and animals are not available. Leucovorin should be given only if the potential benefit justices the potential risk to the fetus because the drug does cross the placenta. Oxaliplatin is a Pregnancy category D which indicates that there is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk from use in pregnant women may be acceptable despite the risk. It is unknown if oxaliplatin crosses the placenta. A 26-year-old woman pregnant with twins was diagnosed with metastatic colonrectal cancer at week 10 of pregnancy. The pregnant mother received 10 courses of a full dose biweekly FOLFOX regimen starting when the …show more content…
First-line therapy for nausea and vomiting in pregnancy include H1 antagonists (diphenhydramine, meclizine, and dimenhydrinate). These medications were are considered first line because they have fewer material side effects and fetal safety is more well-established than other drugs. Second-line therapy for nausea and vomiting include prochlorperazine, metoclopramide, promethazine, droperidol, and ondansetron. Studies have shown that the uses of these medications during the early trimesters have not been associated with increase risk of congenital malformations. Promethazine did appear to lower the seizure threshold in pregnant