Propofol Case Study

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Propofol is a short-acting intravenous anesthetic drug with an excellent recovery profile having pharmacokinetic characteristics particularly suitable for continuous infusion [1,2]. Although propofol is commonly used for induction and maintenance of anesthesia in obese patients, little is known about its tolerated and effective dose in such patients [3]. Obese individuals have larger lean body and fat masses compared to non-obese of the same age, gender, and height. The altered physiological changes that accompany obesity include an increase in blood volume, body water, muscle mass and cardiac output. These factors affect the volumes of drug distribution and total body clearance [4,5]. Dose adjustment for these changes needs
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While the onset time (min) was the time from the beginning of propofol infusion until the BIS level became less than 50. The dose of propofol infusion (mg/kg/h) required to reach the onset time. The rate of infusion during maintenance (mg/kg/h) and the total amount of propofol (mg) used during the entire anesthesia. The clinical evaluation of the recovery of anesthesia was achieved by calculating the time for spontaneous breathing (TSB) and the time for eye opening (TEO). TSB (min) was the time from the stoppage of propofol infusion to the return of spontaneous breathing. TEO (min) was the time from the stoppage of propofol infusion until patients open their eyes. The recovery time (min) was defined as the time from the stoppage of propofol infusion until the moment where BIS level was higher than 90. Time to discharge (min) was defined as the time from patient arrival to the time of patient discharge from the recovery room. For the purpose of the study, heart rate and mean blood pressure were recorded just before induction of anesthesia (T0), then every 3 minutes after induction for 15 minutes. Afterwards, these values were recorded every 10 minutes till the end of …show more content…
Chi-squared (χ2) or Fisher’s exact test was used when appropriate. Also, paired t-test was applied as needed. Ordinal data are expressed as mean ± SD and categorical data are expressed as number of patients (n). Sample size of 18 patients per group was required to detect a 30% difference in propofol requirements (α = 0.05 and β = 0.1). To compensate for possible dropout, we boosted the number to 25 patients in each

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