Prokaryotes can be recognized as a single-celled organism that lack the extensive internal compartments. Unlike eukaryotes, the prokaryotes concentrated their genetic materials in a small portion of cell’s cytoplasm known as nucleoid. Almost entire prokaryotic genome is contained in a single circular DNA strand that is supercoiled. Some additional genes are located on an independent small, circular or linear plasmids which coding for extra properties likes antibiotic resistance (Brown, 2002). Typically, prokaryotes lack of genetic organization compared to eukaryotes. So, they own a special feature in which most of the genes are arranged as families or clusters of coregulated genes which known as operons while other genes may float at random
