Product Description Of Tretasubtitute Peptide Hormone Essay

1503 Words 7 Pages
CJC-1295 (DAC) is tretasubtitute peptide hormone which is an improved version of GRF 1-29 with DAC (Drug affinity complex). It is a synthetic hormone that imitates the functioning of GHRH (growth hormone-releasing hormone or growth hormone-releasing factor (GRF)), as such, it is a growth hormone secretagogue. CJC-1295 (DAC) has a longer half-life compared to GHRH (1-29) as a result of its enhanced pharmacokinetics. These improvements are achieved as a result of the DAC-complex which increases its binding affinity with GHRH receptors and hence protecting the hormone from enzymatic degradation which normally reduces its half-life. CJC-1295 (DAC) bioconjugates with serum albumin and as such its half-life is extended as well as its therapuetic window. CJC-1295 (DAC) establishes protective groups around the amino acids of GHRH which are vulnerable to enzymatic degradation. CJC-1295 (DAC) is made up of 30 amino acids and a molecular mass of 3647.28 while its molecular formula is C165H269N47O46. Its amino acid sequence is Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-LysLys(Maleimidopropionyl)-NH2 (Drug Affinity Complex). As an analogue of GHRH, CJC-1295 (DAC) posessess D-Ala, Gln, Ala, and Leu replacements at points 2, 8, 15, and 27 respectively. CJC-1295 (DAC) has a half-life of about 7 days compared to that of CJC-1295 without DAC which is about 30 minutes.…

Related Documents