The most common cause of the intrarenal injury is secondary to surgery but may also be caused by severe sepsis, obstetric complications, or trauma like burns. During these events a reduction in ATP occurs within the cells creating oxygen free radicals as a result of anaerobic metabolism causing cellular injury, swelling and eventually necrosis. This in turn activates the inflammaorty process the release of cytokines causing tubular injury. Furthermore, the transport of sodium and molecules is disrupted by damage to the proximal tubular epithelium (McCance & Huether,
The most common cause of the intrarenal injury is secondary to surgery but may also be caused by severe sepsis, obstetric complications, or trauma like burns. During these events a reduction in ATP occurs within the cells creating oxygen free radicals as a result of anaerobic metabolism causing cellular injury, swelling and eventually necrosis. This in turn activates the inflammaorty process the release of cytokines causing tubular injury. Furthermore, the transport of sodium and molecules is disrupted by damage to the proximal tubular epithelium (McCance & Huether,