Preimplantation genetic diagnosis change the way of medical practice rapidly.[56]The main purpose of Preimplantation genetic diagnosis (PGD) is to test embryos for couples with the hereditary condition before embryo transfer to avoid transmitting the genetic abnormality to their couples. [57] The couple must go through IVF procedures to grow embryos in vitro. The in vitro cultured embryos can be biopsied at different developmental stages either the zygote, cleavage or trophectoderm stage.[56, 58]
Classical methods such as FISH technique and single cell PCR empowered PGD to Screen different hereditary disorder, in particular single gene disorders such as thalassemia and sickle cell anemia, in spite of several complications and limitations
Classical methods such as FISH technique and single cell PCR empowered PGD to Screen different hereditary disorder, in particular single gene disorders such as thalassemia and sickle cell anemia, in spite of several complications and limitations