Polyneuropathy Pathology

Polyneuropathy commonly arises from diabetes, autoimmune diseases, toxins, and nutritional deficiency to secondary alcoholism. The pathophysiology’s associated with polyneuropathy are symmetrical involvement of multiple nerve fibers, which results in stocking/glove distribution of sensation. In addition, demyelination of distal part long axons because of the increase in myelin. Moreover, degeneration of the distal part of long axon because inadequate axonal transport to distal ends of axons. The pathology of polyneuropathy will lead to several sensory, motor, and autonomic function changes. Primarily, demyelination and degeneration of axons, it will lead to changes in sensory function, resulting in decreased sensation or impaired vibration senses. In addition, changes to motor function resulting in muscle atrophy, decreased reflexes, abnormal stress to joints, and difficulty walking on toes. The most severe manifestation of motor function is muscle weakness because it can progress to total motor paralysis and death from respiratory failure (Kuwabara, 2004). Furthermore, changes to autonomic functions, resulting in will lead to difficulties gastrointestinal, genitourinary, cardiovascular, and sweating dysfunctions. Of the autonomic changes, management of …show more content…
Therefore, this might impact MK recovery because the PNS responsible for controlling all sensory, motor, and autonomic functions. Sensory problems may cause decreased sensation, numbness, pain, paresthesias, and dyesthesia. In addition, motor function may cause muscle weakness, poor balance and poor coordination. Moreover, autonomic problems may cause orthostatic hypotension, impaired sweating, bladder, bowel, and genital dysfunction. Although several problems arise in the PNS there are a few problems that will not exist during recovery are problems with consciousness, communication, and