Phyllanthus Niruri Essay

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Phyllanthus niruri
Extracts of Phyllanthus niruri have been studied for biological activities in various animal models and in vitro models and reported to possess significant antimicrobial, antiviral, hepato protective, antioxidant, anticancer, anti-inflammatory, antiplasmodial, antiurolithiatic and diuretic. The phytochemical studies were characterized and the presence of various compounds such as lignans, phyllanthin, hypophyllanthin, flavonoids, glycosinoids & tannins was mentioned (Narendra et al., 2012).
Previous clinical studies demonstrated that P. niruri had no acute or chronic toxicity, and preliminary data suggested the effects, which promote stone elimination in stone-forming patients, as well as the normalization of calcium levels
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(2013) study on the polyherbal formulation of Aerva lanata with other herbs at a dose of 100 and 200 mg/kg decreased the levels of calcium and phosphate in the urine, serum uric acid, creatinine, urea and BUN in ethylene glycol (0.75%) induced urolithic rats. It also enhanced the urine pH, volume and magnesium content. The anti-urolithic activity was further evidenced by the histological evaluation, that is, decrease in the deposition of crystals in the kidney sections, tubular dilatation and necrosis.
Soundararajan et al. (2006) study on the effect of Aerva lanata aqueous suspension reduced the urinary levels of stone promoters such as oxalate, calcium, uric acid, phosphorus and protein and increased the content of stone inhibitors citrate and magnesium. The oxalate synthesising enzymes that is, lactate dehydrogenase and glycolic acid oxidase also lessened in the liver and kidneys. The histopathological studies showed dissolution of calcium oxalate stones compared to disease control

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