Table 2 lists the pharmacokinetic parameters calculated from the plasma concentrations of the three PFCs in rats that received a single IV and oral administration of PFOA (1 mg/kg), PFOS (2 mg/kg), and PFHxS (4 mg/kg). The concentration–time profiles of 3 PFCs are shown in Figure 4. The one- or two-compartment model best fitted the majority of the data. The pharmacokinetic parameters of PFOA were estimated after a single oral and IV administration of 1 mg PFOA/kg body weight and followed up for 24 h. The one-compartment model was best fitted for PFOA. After the oral administration to female rats, the Cmax and AUC0-∞ were 5.41 ± 0.38 µg/mL and 37.20 ± 2.50 µg·h/mL. The t1/2, V/F, and CL/F were 3.49 ± 0.19 h, 135.51 ± 13.31 mL/kg, and 26.88 ± 1.81 mL/h, respectively.
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The t1/2, V, and CL were 4.65 ± 0.24 h, 171.37 ± 11.19 mL/kg, and 25.54 ± 1.36 mL/h, respectively. For the PFOS study, the pharmacokinetic parameters were evaluated after a single oral and IV administration of 2 mg PFOS/kg body weight and followed up for 70 days. The PFOS data were well fitted with two-compartment model. The Cmax and AUC0-∞ of PFOS after the oral administration were 6.71 ± 0.31 µg/mL and 6547.06 ± 507.93 µg·h/mL, respectively. The t1/2, V, and CL/F were 634.98 ± 68.97 h, 279.85 ± 17.34 mL/kg, and 0.31 ± 0.02 mL/h, respectively. In the case of IV administration of PFOS to the female rats, the AUC0-∞ was 5195.18 ± 217.29 …show more content…
In addition, a simple and reliable UPLC-MS/MS method was successfully developed and validated for the simultaneous determination of PFOA, PFOS, and PFHxS in rat plasma and tissues. We believe that the present study could be used to develop physiologically-based pharmacokinetics of perfluorinated
The t1/2, V, and CL were 4.65 ± 0.24 h, 171.37 ± 11.19 mL/kg, and 25.54 ± 1.36 mL/h, respectively. For the PFOS study, the pharmacokinetic parameters were evaluated after a single oral and IV administration of 2 mg PFOS/kg body weight and followed up for 70 days. The PFOS data were well fitted with two-compartment model. The Cmax and AUC0-∞ of PFOS after the oral administration were 6.71 ± 0.31 µg/mL and 6547.06 ± 507.93 µg·h/mL, respectively. The t1/2, V, and CL/F were 634.98 ± 68.97 h, 279.85 ± 17.34 mL/kg, and 0.31 ± 0.02 mL/h, respectively. In the case of IV administration of PFOS to the female rats, the AUC0-∞ was 5195.18 ± 217.29 …show more content…
In addition, a simple and reliable UPLC-MS/MS method was successfully developed and validated for the simultaneous determination of PFOA, PFOS, and PFHxS in rat plasma and tissues. We believe that the present study could be used to develop physiologically-based pharmacokinetics of perfluorinated