Newton AMJ et al were designed to develop a delayed release matrix tablets by using various natural polymers. The polysaccharide Pectin was used in the formulation Vs. Xanthan gum and Guar gum. The performance of Pectin Vs. other conventional polysaccharides was demonstrated in this work. A model drug Propranolol HCl was incorporated in the formulation design in order to access the drug release profile from the developed matrix system. The polysaccharide based formulation are known for stability issues and manufacturing difficulties. The research was focused on developing industrially relevant direct compression techniques. The polymers were used in different concentration ratios to optimize the best formulation design.
